ArticleJACC. Advances2024
Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging.Annals of neurology · 2026Article
- Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.Nutrients · 2026Article
- Intrinsic capacity and quality of life trajectories in older Europeans by sex and region.Research square · 2026Article
- A systematic review of the association between phase angle and cognitive function among older adults.GeroScience · 2026Review
- Intrinsic capacity as a determinant of quality of life trajectories in older Europeans: A sex- and region-sensitive longitudinal analysis using SHARE.Research square · 2026Article
- Serum uric acid levels and longitudinal change in cognitive function in older adults: a sex-stratified population-based study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- External validation of dementia risk prediction models in the EPIC-Norfolk cohort: a UK-based cohort study.NPJ dementia · 2026Article
- Sex Differences in the Impact of Atherosclerotic Cardiovascular Risk Burden on Cognitive Health.Journal of the American Heart Association · 2025Article
- Health Equity Across the Life Course: A Call to Action for the Cardiovascular Community.JACC. Advances · 2024Article
- Navigating the Intersection of Sex, Vascular Risk Factors, and Cognitive Decline.JACC. Advances · 2024Article
- Alzheimer's disease model explains Alzheimer's disease incidences.Journal of Alzheimer's disease reportsArticle
- Polypharmacy is associated with lower progression from MCI to Alzheimer's disease, with sex-specific patterns across drug classes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Age-related cognitive decline is accelerated by vascular risk factors for cerebral small vessel disease. However, the association of vascular risk factors with cerebral small vessel disease contributing to the sex differences in cognitive decline remains unclear. Objectives: The purpose of this study was to evaluate sex differences in cognitive decline and the association between vascular risk factors and cognitive decline by sex. Methods: We used data from the UK Biobank (>55 years of age; n = 19,067) to assess cognitive tests (executive function, processing speed, and memory) while adjusting for baseline measurements to examine how vascular risk factors affect cognition. A univariate regression analysis was used to assess sex differences at the first time point (2014). A repeated measure analysis with a mixed effect model was used to determine cognitive decline (between 2014 and 2019). Any significant interaction between vascular risk factors and sex was investigated. Results: Females had lower scores in all 3 domains at the first cognitive tests (2014). We found a significant sex-by-time interaction over a 5-year period in matrix pattern completion ( Conclusions: The rate of cognitive decline did not differ significantly between males and females. However, the impact of several vascular risk factors on cognitive decline was greater in females than in males.
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