Evidence map›Paper›PMID 39129875›Full record

ArticleGastro hep advances2023

The Ratio of Activin A and Follistatin-Like 3 Is Associated With Posthepatectomy Liver Failure and Morbidity in Patients Undergoing Liver Resection.

Jonas Santol, David Pereyra, Stefanie Haegele, Daphni Ammon, Gregor Ortmayr, Anita Pirabe, Jan Philipp Jonas, Stefan Schuster, Sarang Kim, Toni Nguyen and 3 more

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Article in Gastro hep advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonas SantolDepartment of Surgery, Vienna Health Network, HPB Center, Clinic Favoriten and Sigmund Freud Private University, Vienna, Austria.
David PereyraDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Stefanie HaegeleDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Daphni AmmonDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Gregor OrtmayrCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Anita PirabeInstitute of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Jan Philipp JonasDepartment of Surgery, Vienna Health Network, HPB Center, Clinic Favoriten and Sigmund Freud Private University, Vienna, Austria.
Stefan SchusterDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Sarang KimDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Toni NguyenDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Thomas GruenbergerDepartment of Surgery, Vienna Health Network, HPB Center, Clinic Favoriten and Sigmund Freud Private University, Vienna, Austria.
Alice AssingerInstitute of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Patrick StarlingerDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Activin A is a key regulator in liver regeneration, but data evaluating its role in humans after hepatic surgery are limited. In this study we explore the predictive role of circulating activin A, its antagonist follistatin-like 3 (FSTL-3), and their ratio for posthepatectomy liver failure (PHLF) and monitor their levels after surgery, to evaluate their role in human liver regeneration. Methods: Activin A and FSTL-3 levels were assessed in 59 patients undergoing liver surgery. Using receiver operating characteristic analysis, we evaluated the predictive potential of activin A, FSTL-3, and their ratio. Results: While perioperative dynamics of activin A and FSTL3 were significantly affected by hepatic resection (activin A Conclusion: Activin A/FSTL-3 ratio predicts PHLF and morbidity. Its significance in preoperative patient assessment needs to be further validated in larger, independent cohorts.

Indexed as

Activin AFollistatin-like 3Liver surgeryPosthepatectomy liver failurePostoperative morbidity

Identifiers

PMID39129875
PMCPMC11307668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.