Evidence map›Paper›PMID 39129539›Full record

ArticleDalton transactions (Cambridge, England : 2003)2024

2-Phenylbenzothiazolyl iridium complexes as inhibitors and probes of amyloid β aggregation.

Karna Terpstra, Yiran Huang, Hanah Na, Liang Sun, Citlali Gutierrez, Zhengxin Yu, Liviu M Mirica

Abstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karna TerpstraDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.
Yiran HuangDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.
Hanah NaDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.ORCID 0000-0002-0576-4806
Liang SunDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.
Citlali GutierrezDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.ORCID 0000-0002-5739-1714
Zhengxin YuDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.
Liviu M MiricaDepartment of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, Illinois 61801, USA. mirica@illinois.edu.ORCID 0000-0003-0584-9508

Funding

Blood-Brain Barrier Permeable Multimodal Imaging Agents for Neurodegenerative DiseasesRF1AG083937 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MIRICA, LIVIU M. · 2023 to 2023
$1.8M
NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
NIA NIH HHS RF1 AG083937NIGMS NIH HHS R01 GM114588
6 · The paper itself

Abstract

The aggregation of amyloid β (Aβ) peptides is a significant hallmark of Alzheimer's disease (AD), and the detection of Aβ aggregates and the inhibition of their formation are important for the diagnosis and treatment of AD, respectively. Herein, we report a series of benzothiazole-based Ir(III) complexes HN-1 to HN-8 that exhibit appreciable inhibition of Aβ aggregation

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBenzothiazolesCoordination ComplexesIridiumProtein AggregatesAnimalsBlood-Brain BarrierBrainHumansMiceThiazoles2-phenylbenzothiazoleAmyloid beta-PeptidesBenzothiazolesCoordination ComplexesIridiumProtein AggregatesThiazoles

Identifiers

PMID39129539
PMCPMC11445708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.