Evidence map›Paper›PMID 39129294›Full record

ReviewCNS & neurological disorders drug targets2025

Exploring the Pharmacological Effects of Bioactive Peptides on Human Nervous Disorders: A Comprehensive Review.

Kuldeep Singh, Jeetendra Kumar Gupta, Aman Shrivastava, Divya Jain, Amrendra Pratap Yadav, Sumeet Dwivedi, Anubhav Dubey, Shivendra Kumar

Abstract readReview
PubMed Publisher
In one paragraph

Review in CNS & neurological disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Serendipitous Discovery of Short Peptides Dimethylammonium Salt Promoting Neural Differentiation.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kuldeep SinghDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.ORCID 0000-0001-8772-8157
Jeetendra Kumar GuptaDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.ORCID 0000-0002-5819-371X
Aman ShrivastavaDepartment of Pharmacology, Institute of Professional Studies, College of Pharmacy, Gwalior, M.P. India.ORCID 0000-0003-0085-4965
Divya JainDepartment of Microbiology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.ORCID 0000-0001-7220-5687
Amrendra Pratap YadavDepartment of Pharmacy, Meerut Institute of Technology, Meerut, U.P., India.ORCID 0000-0003-0470-2336
Sumeet DwivediDepartment of Pharmacognosy, Acropolis Institute of Pharmaceutical Education and Research, Indore (M.P.), India.ORCID 0000-0003-3592-4812
Anubhav DubeyDepartment of Pharmacology, Maharana Pratap College of Pharmacy, Kanpur, Uttar Pradesh, India.ORCID 0000-0002-9089-4794
Shivendra KumarDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.ORCID 0000-0002-2287-6981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A family of peptides known as bioactive peptides has unique physiological properties and may be used to improve human health and prevent illness. Because bioactive peptides impact the immunological, endocrine, neurological, and cardiovascular systems, they have drawn a lot of interest from researchers. According to recent studies, bioactive peptides have a lot to offer in the treatment of inflammation, neuronal regeneration, localized ischemia, and the blood-brain barrier. It investigates various peptide moieties, including antioxidative properties, immune response modulation, and increased blood-brain barrier permeability. It also looks at how well they work as therapeutic candidates and finds promising peptide-based strategies for better outcomes. Furthermore, it underscores the need for further studies to support their clinical utility and suggests that results from such investigations will enhance our understanding of the pathophysiology of these conditions. In order to understand recent advances in BPs and to plan future research, academic researchers and industrial partners will find this review article to be a helpful resource.

Indexed as

Nervous System DiseasesPeptidesAnimalsBlood-Brain BarrierHumansPeptidesBioactive peptidesblood-brain barrier permeabilityfocal ischemiaglutathioneinflammationneurodegenerative diseasesnutraceuticalpathways.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.