Evidence map›Paper›PMID 39129287›Full record

ReviewCurrent medicinal chemistry2025

Trends and Implications of Ribosome-associated Protein Quality Control in Diseases: A Bibliographic Analysis.

Leijie Chen, Wanjuan Song, Yumin Qing, Yuyong Tan, Jia Liu, Liang Lv

Abstract readReview
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In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leijie ChenDepartment of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0001-5275-4638
Wanjuan SongDepartment of Obstetrics and Gynecology, Reproductive Medicine Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yumin QingDepartment of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0009-0002-2996-9774
Yuyong TanDepartment of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-0571-3136
Jia LiuCenter of Medical Research, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-9319-5841
Liang LvDepartment of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-5507-3982

Funding

Natural Science Foundation of Hunan Province 2021JJ30941, 2022JJ30824
6 · The paper itself

Abstract

objectiveRibosome-associated protein Quality Control (RQC), comprising several well-organized processes and crucial factors, provides translational surveillance in cells by recognizing and degrading aberrant nascent proteins arising from ribosome stalling. Although rapid progress has been made in RQC, a bibliographic analysis of RQC-related literature studies for the overall trends and research progress, particularly the correlation of RQC with diseases, is absent.

methodsWe obtained scientific outputs of global RQC between 1999 and 2022 by Web of Science Core Collection (WoSCC). CiteSpace, VOSviewer, and a package of R called bibliometrix were applied to explore the current research status, hotspots, and the relationship between RQC and diseases.

resultsA total of 429 articles have been included in this study, and the number of published studies increases annually. The United States and Germany have been found to lead in this field. An analysis of the keywords has shown "initiation", "aggregation", "structure basis", "elongation", and "degradation" to be the emerging themes of RQC. Keywords co-occurrence has shown E3 ubiquitin ligase to bridge RQC and neurodegeneration.

conclusionThrough a summary of the current studies on RQC, our study has provided evolutionary trends and frontiers in this field by mathematical analysis and visualization, implying the potential of RQC in neurodegeneration and other diseases.

Indexed as

Ribosomal ProteinsRibosomesHumansQuality ControlRibosomal Proteinsbibliographic analysiscellular response.CiteSpaceRibosome-associated protein quality controlribosome collisionVOSviewer

Identifiers

PMID39129287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.