ArticleCurrent drug metabolism2024
Hydrogen Peroxide Induces Ethanol-inducible CYP2E1
Article in Current drug metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimsThe aim of the present study is to elucidate the mechanism of CYP2E1 induction as a causative factor of Alcoholic Hepatitis (AH) and its relationship with inflammation.
backgroundChronic alcohol consumption induces CYP2E1, which is involved in the development of Alcoholic Hepatitis (AH). However, the mechanisms underlying the induction of CYP2E1 by alcohol remain unclear. Therefore, we herein investigated the induction of drug-metabolizing enzymes, particularly CYP2E1, by hydrogen peroxide (H
objectiveThe mechanisms underlying the induction of CYP2E1 by H
methodsWe assessed changes in the expression of drug-metabolizing enzymes in the human hepatoma cell line, Hep3B, following treatment with H
resultsThe induction of CYP2E1 by H
conclusionWe herein demonstrated that the expression of CYP2E1 was induced by H
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