ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024
Association between "weekend warrior" physical activity and the incidence of neurodegenerative diseases.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The weekend warrior phenomenon: comparable mortality reduction to regular exercise with enhanced neuroprotective effects-a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Weekend warrior and the risk of specific disease: a meta-epidemiology study.BMC public health · 2025Pooled it
- Longitudinal association between the weekend warrior physical activity pattern and cognitive function trajectories among middle-aged and older Chinese adults.Archives of public health = Archives belges de sante publique · 2026Article
- The Association Between "Weekend Warrior" Physical Activity Pattern and Neuropsychological Outcomes: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Associations of "weekend warrior" and other physical activity patterns with sarcopenia among older adults in China: a cross-sectional study.BMC public health · 2026Article
- Association of the "Weekend Warrior" and other leisure-time physical activity patterns with neurological disorders in adulthood: a UK biobank study.Journal of neurology · 2026Article
- Association of weekend warrior physical activity pattern with dyslipidemia among South Korean workers.Frontiers in cardiovascular medicine · 2026Article
- Association between frequency of meeting daily step thresholds and all-cause mortality and cardiovascular disease in older women.British journal of sports medicine · 2025Article
- Dietary and Physical Activity Approaches to the Management of High Blood Pressure.Current atherosclerosis reports · 2025Review
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Accelerometer-derived physical activity patterns and incident type 2 diabetes: a prospective cohort study.The international journal of behavioral nutrition and physical activity · 2025Article
- Accelerometer-derived "weekend warrior" physical activity, sedentary behavior, and risk of dementia.Alzheimer's research & therapy · 2025Article
- Can weekend warriors and other leisure-time physical activity patterns reduce the atherogenic index of plasma (AIP)? A cross-sectional analysis based on NHANES 2007-2018.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While guidelines recommend 150 min of moderate to vigorous physical activity (MVPA) weekly to enhance health, it remains unclear whether concentrating these activities into 1-2 days of the week, "weekend warrior" (WW) pattern, has the same benefit for neurodegenerative diseases (NDDs). This study aimed to evaluate the associations of WW pattern and the risk of NDDs. This prospective study was conducted using accelerometer-based physical activity data for a full week from June 2013 to December 2015 in the UK Biobank. These individuals were categorized into distinct physical activity patterns, including the WW pattern (i.e., over 50% or 75% of recommended MVPA achieved over 1-2 days), regular pattern, and inactive pattern. Cox proportional hazards model was used to evaluate the association between physical activity patterns and outcomes. Compared to inactive group, WW pattern and regular pattern was similarly linked to a reduced risk of all-cause dementia (WW: Hazard Ratio [HR]: 0.68, 95% Confidence Interval [CI]: 0.56-0.84; regular: HR: 0.86, 95% CI: 0.67-1.1) and all-cause Parkinsonism (WW: HR: 0.47, 95% CI: 0.35-0.63; regular: HR: 0.69, 95% CI: 0.5-0.95). When the exercise threshold was increased to 75% of MVPA, both patterns still were associated with decreased risk of incident all-cause dementia (WW: HR: 0.61, 95% CI: 0.41-0.91; regular: HR: 0.76, 95% CI: 0.63-0.92) and all-cause Parkinsonism (WW: HR: 0.22, 95% CI: 0.10-0.47; regular: HR: 0.59, 95% CI: 0.46-0.75). Concentrating recommended physical activities into 1-2 days per week is associated with a lower incidence of NDDs.
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