ArticleBMC oral health2024
A study of risk factors associated with the presence of oral potentially malignant disorders: a community-based study from Northeastern Thailand.
Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Head and neck cancer: a comprehensive review of epidemiology, global burden and advances in radiotherapy.Journal of the Egyptian National Cancer Institute · 2026Review
- Cysteine suppresses the progression of oral squamous cell carcinoma via regulatingTranslational cancer research · 2026Article
- Trends and disparities in the burden of oral cancer in Southeast Asia, 1990 to 2023: a retrospective analysis based on the Global Burden of Disease 2023 data.Journal of Yeungnam medical science · 2026Article
- Biomaterial-based therapeutic strategies for oral submucous fibrosis.Frontiers in cell and developmental biology · 2026Review
- Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.BMC oral health · 2025Article
- Prevalence and determinants of oral potentially malignant disorders in western rajasthan.Scientific reports · 2025Article
- Prognostic factors for recurrence and malignant transformation after treatment of oral epithelial dysplasia: A mixed cohort study.PloS one · 2025Article
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5 authors.
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Abstract
backgroundThe principal objective of this study is to ascertain the connections between well-known risk factors of oral cancer, including smoking (cigarette and tobacco), alcohol consumption, betel quid chewing, irritations in the oral cavity, history of head and neck cancer, and history of working outdoor more than 4 days/week, and the presence of OPMDs within the Thai population.
method349,318 subjects were recruited for initial screening, then 1,483 subjects who had at least 1 risk factor and a suspicious lesion underwent comprehensive oral examinations followed by a clinical diagnosis and then received initial treatment from either oral surgeons or oral medicine specialists. Among these subjects, individuals with at least 1 risk factor and with a clinical diagnosis of OPMDs were classified as cases, while those with at least 1 risk factor but without OPMDs were categorized as controls. The case group comprised a total of 487 subjects, whereas the control group consisted of 996 subjects. Exclusion criteria were known cases of currently having oral cancer or OPMDs.
resultsThe outcomes of the multivariate analysis revealed that among the variables assessed, betel quid (adjusted OR 5.12 [3.93-6.68], p < 0.001) and smoking (adjusted OR 1.46 [1.08-1.97], p = 0.013), there were an association with the presence of OPMDs. Conversely, alcohol drinking, having irritations in the oral cavity, a history of head and neck cancer, and a history of working outdoors more than 4 days/week were not associated with the presence of OPMDs. Furthermore, we also study the synergistic effect of alcohol drinking, irritations in the oral cavity, history of head and neck cancer, and history of working outdoors more than 4 days/week using subgroup analysis. The analysis showed that alcohol consumption combined with smoking or betel quid chewing expressed a significantly increased risk of OPMDs, from 1.46 to 2.03 (OR 2.03 [1.16-3.56], p = 0.014) and from 5.12 to 7.20 (OR 7.20 [3.96-13.09], p < 0.001).
conclusionSmoking and exposure to betel quid were a significant risk factors for the presence of OPMDs. The combination of alcohol with smoking or betel quid chewing was also found to increase the risk of OPMDs in this Thai northeastern population.
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