Evidence map›Paper›PMID 39129009›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024

Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis.

Kecheng Yuan, Qingyun Liu, Penghui Luo, Changliang Wang, Yufu Zhou, Fulang Qi, Qing Zhang, Xiaoyan Huang, Bensheng Qiu

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Comment on "Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis".Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kecheng YuanMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Qingyun LiuMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Penghui LuoMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Changliang WangMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Yufu ZhouAnhui Fuqing Medical Equipment Co., Ltd., Hefei, China.
Fulang QiMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Qing ZhangMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China.
Xiaoyan HuangAnhui Fuqing Medical Equipment Co., Ltd., Hefei, China.
Bensheng QiuMedical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, China. bqiu@ustc.edu.cn.ORCID http://orcid.org/0000-0003-2987-7378

Funding

Key Research and Development Program of Sichuan Province 2022YFB4702704
6 · The paper itself

Abstract

This study aimed to evaluate the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, assessing its effectiveness as a biomarker for osteoporosis. A systematic review was conducted by two independent researchers using Cochrane, PubMed, EMBASE, and Web of Science databases up to December 2023. Quality assessments were evaluated using the Cochrane risk of bias tool and the Agency for Healthcare Research and Quality (AHRQ) checklist. Fourteen studies involving 1495 patients were analyzed. The meta-analysis revealed a significant difference in PDFF values between the osteoporosis/osteopenia group and the normal control group, with a mean difference of 11.04 (95% CI: 9.17 to 12.92, Z=11.52, P < 0.00001). Measuring PDFF via MRI shows potential as an osteoporosis biomarker and may serve as a risk factor for osteoporosis. This insight opens new avenues for future diagnostic and therapeutic strategies, potentially improving osteoporosis management and patient care.

objectiveThis study aims to assess the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, evaluating its effectiveness as a biomarker for osteoporosis. MATERIALS AND

methodsThis systematic review was carried out by two independent researchers using Cochrane, PubMed, EMBASE, and Web of Science databases up to December 2023. Quality assessments were evaluated using the Cochrane risk of bias tool and the Agency for Healthcare Research and Quality (AHRQ) checklist.

resultsFourteen studies involving 1495 patients were analyzed. The meta-analysis revealed a significant difference in PDFF values between the osteoporosis/osteopenia group and the normal control group, with a (MD = 11.04, 95% CI: 9.17 to 12.92, Z = 11.52, P < 0.00001). Subgroup analyses indicated that diagnostic methods, gender, and echo length did not significantly impact the PDFF-osteoporosis association.

conclusionPDFF measurement via MRI shows potential as an osteoporosis biomarker and may serve as a risk factor for osteoporosis. This insight opens new avenues for future diagnostic and therapeutic strategies, potentially improving osteoporosis management and patient care.

Indexed as

Bone MarrowOsteoporosisAdipose TissueBiomarkersBone DensityHumansMagnetic Resonance ImagingProtonsRisk FactorsBiomarkersProtonsFat fraction quantifiedMeta-analysisMRIOsteopenia/osteoporosisPDFF

Identifiers

PMID39129009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.