Evidence map›Paper›PMID 39128979›Full record

ArticleWorld journal of microbiology & biotechnology2024

Regulation of carbon metabolic fluxes to enhance lipid and succinate production in oleaginous fungus Mortierella alpina.

Chongran Sun, Tao Yang, Shuangfei Zhang, Qikun Wen, Binyuan Gao, Qianzi Liu, Haina Cheng, Yuguang Wang, Zhu Chen, Hongbo Zhou

Abstract read
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In one paragraph

Article in World journal of microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chongran SunDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Tao YangDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Shuangfei ZhangDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Qikun WenDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Binyuan GaoDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Qianzi LiuDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Haina ChengDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Yuguang WangDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China.
Zhu ChenDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China. zhuchen@csu.edu.cn.
Hongbo ZhouDepartment of Bioengineering, School of Minerals Processing and Bioengineering, Central South University, 932 South Lushan Road, Changsha, 410083, Hunan, P.R. China. zhouhb@mail.csu.edu.cn.

Funding

The Natural Science Foundation of Hunan Province Grant No. 2021JJ30803The Start-up Funding of Central South University Grant No. 202045023
6 · The paper itself

Abstract

Mortierella alpina is popular for lipid production, but the low carbon conversion rate and lipid yield are major obstacles for its economic performance. Here, external addition of organic acids involved in tricarboxylic acid cycle was used to tune carbon flux and improve lipid production. Citrate was determined to be the best organic acid that can be used for enhancing lipid production. By the addition of citrate, the lipid titer and content were approximately 1.24 and 1.34 times higher, respectively. Meanwhile, citrate supplement also promoted the accumulation of succinate, an important value-added platform chemical. Owing to the improved lipid and succinate production through adding citrate, the carbon conversion rate of M. alpina reached up to 52.17%, much higher than that of the control group (14.11%). The addition of citrate could redistribute carbon flux by regulating the expression level of genes related to tricarboxylic acid cycle metabolism. More carbon fluxes flow to lipid and succinate synthesis, which greatly improved the carbon conversion efficiency of M. alpina. This study provides an effective and straightforward strategy with potential economic benefits to improve carbon conversion efficiency in M. alpina.

Indexed as

CarbonCitric AcidCitric Acid CycleMortierellaSuccinic AcidFermentationGene Expression Regulation, FungalLipid MetabolismLipidsCarbonCitric AcidLipidsSuccinic AcidCarbon conversionCarbon fluxLipidMortierella alpinaSuccinic acid

Identifiers

PMID39128979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.