Evidence map›Paper›PMID 39128947›Full record

ReviewHeart failure reviews2024

The utility of urine sodium-guided diuresis during acute decompensated heart failure.

Hasan K Siddiqi, Zachary L Cox, Lynne W Stevenson, Kevin Damman, Jozine M Ter Maaten, Brian Bales, Jin H Han, Juan B Ivey-Miranda, JoAnn Lindenfeld, Karen F Miller and 8 more

Abstract readReview
In one paragraph

Review in Heart failure reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hasan K SiddiqiDepartment of Medicine, Vanderbilt University Medical Center, North Tower, 1215 21st Avenue South, 5th Floor, Office 5033C, Nashville, TN, 37232-8802, USA. hasan.siddiqi@vumc.org.ORCID 0000-0002-2274-9405
Zachary L CoxDepartment of Pharmacy, Lipscomb University College of Pharmacy, Nashville, TN, USA.
Lynne W StevensonDepartment of Medicine, Vanderbilt University Medical Center, North Tower, 1215 21st Avenue South, 5th Floor, Office 5033C, Nashville, TN, 37232-8802, USA.
Kevin DammanDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jozine M Ter MaatenDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Brian BalesDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jin H HanDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Juan B Ivey-MirandaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
JoAnn LindenfeldDepartment of Medicine, Vanderbilt University Medical Center, North Tower, 1215 21st Avenue South, 5th Floor, Office 5033C, Nashville, TN, 37232-8802, USA.
Karen F MillerDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Henry OoiDepartment of Medicine, Vanderbilt University Medical Center, North Tower, 1215 21st Avenue South, 5th Floor, Office 5033C, Nashville, TN, 37232-8802, USA.
Veena S RaoDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Kelly SchlendorfDepartment of Medicine, Vanderbilt University Medical Center, North Tower, 1215 21st Avenue South, 5th Floor, Office 5033C, Nashville, TN, 37232-8802, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ryan WalshDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jesse WrennDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey M TestaniDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Sean P CollinsDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Partners Heart Failure NetworkU01HL084877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI STEVENSON, LYNNE W · 2006 to 2011
$2.9M
Vanderbilt Interdisciplinary Hospital-Based Systems of Care Research and Training ProgrAm (VISTA)T32HL170986 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SUNIL KRIPALANI, ALAN B STORROW · 2024 to 2026
$1.3M
DEVELOPMENT AND EVALUATION OF COMMUNITY ASTHMA PROGRAMR01HL045293 · NHLBI · WASHINGTON UNIVERSITY · PI FISHER, EDWIN B · 1990 to 1994
–
NHLBI NIH HHS R01 HL045293NHLBI NIH HHS T32 HL170986NHLBI NIH HHS U01 HL084877
6 · The paper itself

Abstract

Diuresis to achieve decongestion is a central aim of therapy in patients hospitalized for acute decompensated heart failure (ADHF). While multiple approaches have been tried to achieve adequate decongestion rapidly while minimizing adverse effects, no single diuretic strategy has shown superiority, and there is a paucity of data and guidelines to utilize in making these decisions. Observational cohort studies have shown associations between urine sodium excretion and outcomes after hospitalization for ADHF. Urine chemistries (urine sodium ± urine creatinine) may guide diuretic titration during ADHF, and multiple randomized clinical trials have been designed to compare a strategy of urine chemistry-guided diuresis to usual care. This review will summarize current literature for diuretic monitoring and titration strategies, outline evidence gaps, and describe the recently completed and ongoing clinical trials to address these gaps in patients with ADHF with a particular focus on the utility of urine sodium-guided strategies.

Indexed as

DiuresisDiureticsHeart FailureSodiumAcute DiseaseHumansDiureticsSodiumAcute decompensated heart failureDecongestionDiuresisDiuretic strategyNatriuresisUrine sodium

Identifiers

PMID39128947
PMCPMC11455821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.