Evidence map›Paper›PMID 39128926›Full record

SynthesisPediatric research2025

Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence.

Anas Elgenidy, Eman F Gad, Islam Shabaan, Hasnaa Abdelrhem, Paula Gamal Wassef, Taher Elmozugi, Mohanad Abdelfattah, Hisham Mousa, Mohamed Nasr, Mostafa Salah-Eldin and 10 more

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Anas ElgenidyFaculty of Medicine, Cairo University, Cairo, Egypt.
Eman F GadPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Islam ShabaanDepartment of Psychiatry, Faculty of Medicine, Al Azhar University, Assiut, Egypt.
Hasnaa AbdelrhemFaculty of Science, Cairo University, Cairo, Egypt.
Paula Gamal WassefFaculty of Medicine, Cairo University, Cairo, Egypt.
Taher ElmozugiFaculty of Medicine, Benghazi University, Benghazi, Libya.
Mohanad AbdelfattahFaculty of Medicine, Cairo University, Cairo, Egypt.
Hisham MousaFaculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed NasrFaculty of Medicine, Al-Azhar University, New Damietta, Egypt.
Mostafa Salah-EldinFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed AltaweelFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Abdelrahman HusseinFaculty of Medicine, Cairo University, Cairo, Egypt.
Mohammad BazzazehFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Mohamed Atef ElganainyFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Ahmed M AliPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Mohamed EzzatFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Amira ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, Jazan, 45142, Saudi Arabia.
Abdulrahman A AlatramDepartment of Psychiatry, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.
Ahmed HammourFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Khaled SaadPediatric Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt. khaled.ali@med.au.edu.eg.ORCID 0000-0002-8473-6116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to investigate the association between autism spectrum disorder (ASD) and atopic eczema (AE), shedding light on potential associations and underlying mechanisms.

methodsA comprehensive review of literature was conducted to identify relevant studies published up to August 2023. Various electronic databases, including PubMed, Embase, Scopus, Web of Science, and Cochrane, were searched using specific keywords related to ASD and AE.

resultsThe meta-analysis covered a total of 30 studies. The first analysis included 23 studies with a combined total of 147430 eczema patients in the ASD group and 8895446 eczema patients in non-ASD group. We calculated the risk ratio of eczema in ASD and non-ASD groups, which revealed a significantly higher risk of eczema in patients with ASD (RR 1.34; 95% CI 1.03, 1.76). The second analysis included seven studies with a combined total of 3570449 ASD patients in the AE group and 3253973 in the non-Eczema group. The risk ratio of ASD in the Eczema and Non-Eczema groups showed an insignificantly increased risk of ASD in patients with eczema (RR 1.67; 95% CI 0.91, 3.06).

conclusionThis study underscores the possible link between ASD and atopic eczema, shedding light on their potential association. IMPACT: Our study conducted a meta-analysis on the association between autism spectrum disorder (ASD) and atopic eczema (AE), shedding light on potential associations and underlying mechanisms. The review we conducted covered a total of 30 studies. This study underscores the possible link between ASD and atopic eczema, shedding light on their potential association.

Indexed as

Autism Spectrum DisorderDermatitis, AtopicChildHumansRisk Factors

Identifiers

PMID39128926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.