Evidence map›Paper›PMID 39128880›Full record

ArticlePhysiological reports2024

Dynamic changes in proresolving lipid mediators and their receptors following acute vascular injury in male rats.

Hideo Kagaya, Alexander S Kim, Mian Chen, Pei-Yu Lin, Xuanzhi Yin, Matthew Spite, Michael S Conte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hideo KagayaCardiovascular Research Institute and Department of Surgery, University of California San Francisco, San Francisco, California, USA.ORCID 0009-0005-8157-1861
Alexander S KimCardiovascular Research Institute and Department of Surgery, University of California San Francisco, San Francisco, California, USA.
Mian ChenCardiovascular Research Institute and Department of Surgery, University of California San Francisco, San Francisco, California, USA.
Pei-Yu LinCardiovascular Research Institute and Department of Surgery, University of California San Francisco, San Francisco, California, USA.
Xuanzhi YinCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Matthew SpiteCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michael S ConteCardiovascular Research Institute and Department of Surgery, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-9119-192X

Funding

Role of Inflammation-Resolving Lipid Mediators In Ischemic RevascularizationR01HL106173 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SPITE, MATTHEW R · 2011 to 2023
$5.7M
Specialized lipid mediators and mechanisms of resolution in vascular injuryR01HL119508 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONTE, MICHAEL S · 2013 to 2016
$1.5M
NHLBI NIH HHS 106173NHLBI NIH HHS 119508NHLBI NIH HHS R01 HL106173NHLBI NIH HHS R01 HL119508
6 · The paper itself

Abstract

Acute vascular injury provokes an inflammatory response, resulting in neointimal hyperplasia (NIH) and downstream pathologies. The resolution of inflammation is an active process in which specialized proresolving lipid mediators (SPM) and their receptors play a central role. We sought to examine the acute phase response of SPM and their receptors in both circulating blood and the arterial wall in a rat angioplasty model. We found that the ratio of proresolving to pro-inflammatory lipid mediators (LM) in plasma decreased sharply 1 day after vascular injury, then increased slightly by day 7, while that in arteries remained depressed. Granulocyte expression of SPM receptors ALX/FPR2 and DRV2/GPR18, and a leukotriene B4 receptor BLT1 increased postinjury, while ERV1/ChemR23 expression was reduced early and then recovered by day 7. Importantly, we show unique arterial expression patterns of SPM receptors in the acute setting, with generally low levels through day 7 that contrasted sharply with that of the pro-inflammatory CCR2 receptor. Overall, these data document acute, time-dependent changes of LM biosynthesis and SPM receptor expression in plasma, leukocytes, and artery walls following acute vascular injury. A biochemical imbalance between inflammation and resolution LM pathways appears persistent 7 days after angioplasty in this model. These findings may help guide therapeutic approaches to accelerate vascular healing and improve the outcomes of vascular interventions for patients with advanced atherosclerosis.

Indexed as

Rats, Sprague-DawleyAnimalsInflammation MediatorsMaleRatsReceptors, G-Protein-CoupledReceptors, Leukotriene B4Vascular System InjuriesInflammation MediatorsReceptors, G-Protein-CoupledReceptors, Leukotriene B4angioplastyinflammationlipid mediatorsneointimaresolution

Identifiers

PMID39128880
PMCPMC11317191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.