Evidence map›Paper›PMID 39128668›Full record

ArticleExperimental eye research2024

MicroRNA-based engineered mesenchymal stem cell extracellular vesicles to treat visual deficits after blast-induced trauma.

Yasaman Anvarinia, Nobel A Del Mar, Ahmed M Awad, Shahadat Hossain, Amritha Tm Seetharaman, Sriram Ravindran, Steven Roth, Rajashekhar Gangaraju

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yasaman AnvariniaDepartment of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 769, Memphis, TN, 38163, USA. Electronic address: yanvarin@uthsc.edu.
Nobel A Del MarDepartment of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 769, Memphis, TN, 38163, USA. Electronic address: ndelmar@uthsc.edu.
Ahmed M AwadDepartment of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 769, Memphis, TN, 38163, USA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura National University, Gamasa, 7731168, Mansoura, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt. Electronic address: ahmedawad@mans.edu.eg.
Shahadat HossainDepartment of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 769, Memphis, TN, 38163, USA. Electronic address: sha_pharm29@yahoo.com.
Amritha Tm SeetharamanDepartment of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Ave, Suite 769, Memphis, TN, 38163, USA. Electronic address: atrikkur@uthsc.edu.
Sriram RavindranDepartment of Oral Biology, College of Dentistry, University of Illinois-Chicago, USA. Electronic address: sravin1@uic.edu.
Steven RothDepartment of Anesthesiology, College of Medicine, University of Illinois-Chicago, USA. Electronic address: rothgas@UIC.EDU.
Rajashekhar GangarajuDepartment of Ophthalmology, Anatomy & Neurobiology, Neuroscience Institute, University of Tennessee Health Science Center, 930 Madison Ave, Suite 768, Memphis, TN, 38163, USA. Electronic address: sgangara@uthsc.edu.

Funding

3D Encapsulation, Bioprinting and Controlled Delivery of Functionally Engineered EVs (FEEs)R01DE030495 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COOPER, LYNDON F, GAJENDRAREDDY, PRAVEEN · 2021 to 2025
$2.3M
Mesenchymal stem cell extracellular vesicles for ischemic retinal damageR01EY033902 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI STEVEN ROTH, Sriram Ravindran · 2022 to 2026
$2.1M
Functional Activation and Targeting of Exosomes for Regenerative MedicineR01DE027404 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAJENDRAREDDY, PRAVEEN, RAVINDRAN, SRIRAM · 2018 to 2022
$2.1M
VRC: Engineered extracellular vesicles for mild TBI-induced retinal injuryR01EY034716 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROTH, STEVEN · 2022 to 2024
$968k
NEI NIH HHS R01 EY033902NEI NIH HHS R01 EY034716NIDCR NIH HHS R01 DE027404NIDCR NIH HHS R01 DE030495
6 · The paper itself

Abstract

Our previous studies have shown the benefit of intravitreal injection of a mesenchymal stem cell (MSC)- derived secretome to treat visual deficits in a mild traumatic brain injury (mTBI) mouse model. In this study, we have addressed whether MSC-derived extracellular vesicles (EV) overexpressing miR424, which particularly targets neuroinflammation, show similar benefits in the mTBI model. Adult C57BL/6 mice were subjected to a 50-psi air pulse on the left side, overlying the forebrain, resulting in mTBI. Sham-blast mice were controls. Within an hour of blast injury, 3 μl (∼7.5 × 10

Indexed as

Blast InjuriesDisease Models, AnimalElectroretinographyExtracellular VesiclesMesenchymal Stem CellsMice, Inbred C57BLMicroRNAsTomography, Optical CoherenceAnimalsIntravitreal InjectionsMaleMesenchymal Stem Cell TransplantationMiceNystagmus, OptokineticVision DisordersVisual AcuityMicroRNAsExtracellular vesiclesGFAPInflammationMesenchymal stem cellsMicrogliamiRNA

Identifiers

PMID39128668
PMCPMC11392619

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.