Evidence map›Paper›PMID 39128498›Full record

ArticleThe American journal of clinical nutrition2024

Total sulfur amino acid requirements are higher during late gestation compared with early gestation in healthy Canadian pregnancies in a repeated-measures trial.

Kerri Scherbinsky, Betina F Rasmussen, Bingqing Li, Dehan Kong, Ronald O Ball, Paul B Pencharz, Glenda Courtney-Martin, Rajavel Elango

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Article in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kerri ScherbinskyDepartment of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada.
Betina F RasmussenBC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
Bingqing LiDepartment of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
Dehan KongDepartment of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
Ronald O BallDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Paul B PencharzDepartment of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Glenda Courtney-MartinDepartment of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada; Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Rajavel ElangoDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: relango@bcchr.ubc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary Reference Intake (DRI) Recommendations for total sulfur amino acids (TSAAs; methionine + cysteine) during pregnancy are based on factorial calculations using data from adult males. To date, no data exist on TSAA requirements obtained directly during pregnancy.

objectivesThe objective of this study was to examine whether TSAA requirements during early (11-20 wk) and late (31-40 wk) gestation in healthy females with singleton pregnancies are different than current recommendations, and different between early and late gestation using the indicator amino acid oxidation (IAAO) technique.

methodsTwenty-five females 20-40 y with a healthy singleton pregnancy were studied using the IAAO technique in a repeated measures design for a total of 70, 8-h d. On each study day a methionine test intake (range: 0-40 mg⋅kg

resultsThe TSAA requirement in healthy pregnant participants in early gestation was 11.1 mg⋅kg

conclusionsWe directly measured TSAA requirements in healthy pregnant mothers, and our findings suggest that requirements are lower than current DRI recommendations of 20 and 25 mg⋅kg

Indexed as

Amino Acids, SulfurNutritional RequirementsAdultCanadaDietFemaleGestational AgeHumansMaternal Nutritional Physiological PhenomenaMethioninePregnancyYoung AdultAmino Acids, SulfurMethionineIAAOmethionineone-carbon metabolismpregnancyrequirementssulfur amino acids

Identifiers

PMID39128498
PMCPMC11473503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.