Evidence map›Paper›PMID 39128100›Full record

ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2024

Diagnostic Significance of Serum Long Noncoding HOX Antisense Intergenic Ribonucleic Acid in Patients with Hepatitis B Virus Related Hepatocellular Carcinoma.

Yue Pan, Meng Cai, Fan Zhang, Xiaoming Liu, Menghua Li, Bingxin Xie, Ju Li

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Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue PanDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Meng CaiDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Fan ZhangDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Xiaoming LiuDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Menghua LiDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Bingxin XieDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.
Ju LiDepartment of Clinical Laboratory, The Public Health Clinical Center of Dalian, Dalian, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsHepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third leading cause of cancer-related mortality. Extensive literature suggests that long noncoding RNAs play a role in the progression of HCC and hold potential as diagnostic biomarkers for this disease. MATERIALS AND

methodsWe examined the serum levels of HOX antisense intergenic RNA (HOTAIR) in 49 hepatitis patients, 31 liver cirrhosis (LC), and 37 HCC patients using quantitative real-time polymerase chain reaction. Correlations between serum HOTAIR levels and clinical data were evaluated in HCC patients. The receiver operating characteristic curve was utilized to analyze the diagnostic potency of HOTAIR.

resultsThe HOTAIR levels in serum were significantly higher in HCC patients compared to those with hepatitis (P = .003) and LC patients (P = .048). There was a significant association between the serum levels of HOTAIR and positivity of hepatitis B e antigen (HBeAg) (P = .039) as well as portal vein tumor thrombus (P = .040) in HCC patients. The area under the curve (AUC) for HOTAIR for distinguishing HCC from hepatitis and LC was 0.697. The combined AUC for HOTAIR, HBeAg, and alpha-fetoprotein (AFP) was 0.777.

conclusionSerum HOTAIR functions as a potential diagnostic marker for hepatitis B virus-related HCC. Combining HOTAIR with clinical data and AFP can reinforce the diagnostic precision on HCC.

Indexed as

Biomarkers, TumorCarcinoma, HepatocellularLiver NeoplasmsRNA, Long NoncodingAdultAgedFemaleHepatitis BHepatitis B, ChronicHepatitis B e AntigensHepatitis B virusHumansLiver CirrhosisMaleMiddle AgedROC CurveBiomarkers, TumorHepatitis B e AntigensHOTAIR long untranslated RNA, humanRNA, Long Noncoding

Identifiers

PMID39128100
PMCPMC11181209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.