ArticleThe Eurasian journal of medicine2024
Vitamins Can Increase Antibiotic Effects Against Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Infection Model.
Article in The Eurasian journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The effects of different forms of vitamin E on gut microbiota, mechanisms, and implications in disease prevention.The Journal of nutritional biochemistry · 2026Review
- Bee venom-derived exosomes combined with metronidazole: antimicrobial effect on Campylobacter jejuni and fibroblast wound healing model.Molecular biology reports · 2026Article
- Antimicrobial and Anti-Efflux Machinery of FDA-Approved Proton Pump Inhibitors and Vitamins AgainstMicroorganisms · 2025Article
- Vitamin D3 potentiates antimicrobial and antibiofilm activities of streptomycin and thymoquinone against Pseudomonas aeruginosa.World journal of microbiology & biotechnology · 2025Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
methodsThe study delves into the antimicrobial properties of vitamins P, K, and E against A. baumannii and P. aeruginosa, employing the minimum inhibitory concentration method and scrutinizing biofilm formation within the A549 cell culture.
resultsThe combined application of vitamins and antibiotics exhibited a statistically significant effect on both the minimal inhibitory concentration values and biofilm formation (P < .05). Within the realm of fat-soluble vitamins, vitamins K and E, when integrated with antibiotics, revealed varying degrees of influence, with vitamin K displaying the most substantial fractional inhibitory concentration value. Vitamin E, on the other hand, demonstrated a comparatively weaker fractional inhibitory concentration than the other constituents. Nevertheless, it exhibited robust optical density and a pronounced capacity to inhibit biofilm formation. Moreover, among the vitamin groups, it is evident that vitamin E surpasses the efficacy of others (antibacterials affecting K < P <E). The collective application of all vitamins manifested the most potent fractional inhibitory concentration.
conclusionThe synergistic effects of vitamins with antibiotics, as evidenced in this study, may offer a promising alternative for treating multidrug-resistant A. baumannii and P. aeruginosa, subject to further investigation through molecular studies.
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Registered trials
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