Evidence map›Paper›PMID 39127975›Full record

ArticleBulletin of experimental biology and medicine2024

Genetic Features of Tongue Cancer Recurrence in Young Adults.

E S Kolegova, A A Schegoleva, R S Vorobev, I K Fedorova, D E Kulbakin, A P Polyakov, A V Mordovsky, L P Yakovleva, A S Vyalov, V T Tsiklauri and 6 more

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

E S KolegovaCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. elenakolegova@oncology.tomsk.ru.
A A SchegolevaCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
R S VorobevCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
I K FedorovaCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
D E KulbakinCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A P PolyakovP. Hertsen Moscow Oncology Research Institute - Branch of National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
A V MordovskyP. Hertsen Moscow Oncology Research Institute - Branch of National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
L P YakovlevaMoscow Clinical Scientific Center named after Loginov, Moscow Healthcare Department, Moscow, Russia.
A S VyalovMoscow Clinical Scientific Center named after Loginov, Moscow Healthcare Department, Moscow, Russia.
V T TsiklauriN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
M A KropotovN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
N G SuchkovaMain Military Clinical Hospital named after academician N. N. Burdenko, Ministry of Defense of the Russian Federation, Moscow, Russia.
N S SukortsevaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
I V ReshetovI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
E L ChoinzonovCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
E V DenisovCancer Research Institute Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.

Indexed as

Exome SequencingNeoplasm Recurrence, LocalTongue NeoplasmsTumor Suppressor Protein p53AdultFemaleFrameshift MutationHumansMaleYoung AdultTP53 protein, humanTumor Suppressor Protein p53mutationsrecurrencesequencingtongue canceryoung adults

Identifiers

PMID39127975

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.