Evidence map›Paper›PMID 39127971›Full record

ArticleBreast cancer research and treatment2024

Variation in surgical treatment by body mass index in patients with invasive lobular carcinoma of the breast.

Israel O Falade, Kayla M Switalla, Molly E Baxter, Astrid Quirarte, Helena Record, Harriet T Rothschild, Elle N Clelland, Rita A Mukhtar

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In one paragraph

Article in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Israel O FaladeSchool of Medicine, University of California - San Francisco, San Francisco, CA, USA.
Kayla M SwitallaMedical School, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
Molly E BaxterDepartment of Surgery, University of California - San Francisco, San Francisco, CA, USA.
Astrid QuirarteDepartment of Surgery, University of California - San Francisco, San Francisco, CA, USA.
Helena RecordDepartment of Surgery, University of California - San Francisco, San Francisco, CA, USA.
Harriet T RothschildSchool of Medicine, University of California - San Francisco, San Francisco, CA, USA.
Elle N ClellandSchool of Medicine, University of California - San Francisco, San Francisco, CA, USA.
Rita A MukhtarDepartment of Surgery, University of California - San Francisco, San Francisco, CA, USA. rita.mukhtar@ucsf.edu.

Funding

Identifying responders to chemotherapy in invasive lobular carcinoma of the breast: development of a multivariable clinical prediction toolK08CA256047 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHTAR, RITA · 2021 to 2025
$1.3M
NCI NIH HHS K08 CA256047NCI NIH HHS K08CA256047
6 · The paper itself

Abstract

purposePatients with invasive lobular carcinoma (ILC) face high rates of positive margins and completion mastectomy, which can be improved with the use of specific techniques, such as oncoplastic surgery. However, prior studies have shown that type of breast cancer surgery performed is also associated with patient factors such as elevated body mass index (BMI). Thus, this study investigates whether BMI impacts the type of surgical interventions in patients with ILC.

methodsA retrospective analysis of 705 patients with stage I-III ILC from an institutional database was conducted. Patients were stratified by BMI (underweight, normal weight, overweight, obese). Pearson's Chi-square, ANOVA, and multivariable logistic regression were used to evaluate the relationship between BMI and surgical procedures.

resultsBreast-conserving surgery (BCS) was the initial operation in 60% of patients, with no significant difference by BMI. Among those undergoing BCS, patients with obese BMI were significantly more likely to undergo oncoplastic surgery (46.9% vs. 7.7%, 37.3%, and 33.6% for underweight, normal, and overweight, respectively, p = 0.032). Obese BMI patients undergoing mastectomy were less likely to have reconstruction compared to those with underweight, normal weight, and overweight BMI (44.2% vs. 50%, 71.1%, and 64.1%, p = 0.002).

conclusionOverweight/obese BMI patients with ILC underwent different surgical interventions compared to those with lower BMI. While initial BCS rates were similar, overweight/obese patients had higher oncoplastic surgery rates in BCS and lower reconstruction rates in mastectomy. Further research is needed to understand BMI's impact on surgical decisions and outcomes in ILC.

Indexed as

Body Mass IndexBreast NeoplasmsCarcinoma, LobularAdultAgedFemaleHumansMammaplastyMastectomyMastectomy, SegmentalMiddle AgedNeoplasm StagingObesityRetrospective StudiesBMIBreast cancerLobularSurgery

Identifiers

PMID39127971
PMCPMC11522173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.