ArticleSleep2025
Sex-specific age-related worsening of pathological endotypic traits in patients with obstructive sleep apnea.
Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- High prevalence of low arousal threshold endotype in obstructive sleep apnea with multiple sclerosis.Sleep & breathing = Schlaf & Atmung · 2026Article
- Review
- Combination of dysfunctional beliefs about sleep and excessive daytime sleepiness as a psychobehavioral characteristic of comorbid insomnia and sleep apnea.Scientific reports · 2026Article
- The upper airway in obstructive sleep apnoea: state of the art.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Expert-level probabilistic breathing event detector informs phenotyping of sleep apnea.Nature communications · 2026Article
- Gerontological Effects on Arousal Frequency, Autonomic Balance, and Slow-Wave Sleep During Pressure Adjustments of CPAP in OSA Patients.Nature and science of sleep · 2026Article
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Obstructive sleep apnea-associated hypertensive disorders in pregnancy: a literature review and clinical management strategies.Reproductive biology and endocrinology : RB&E · 2025Review
- Obstructive Sleep Apnea Syndrome in women: gender in sleep respiratory medicine is a first step towards personalized medicine.Sleep & breathing = Schlaf & Atmung · 2025Review
- Increased loop gain and upper airway collapsibility among smoking patients with obstructive sleep apnoea.ERJ open research · 2025Article
- Big data approaches for novel mechanistic insights on sleep and circadian rhythms: a workshop summary.Sleep · 2025Article
- Sex Differences in Atherosclerotic Cardiovascular Disease Risk in Obstructive Sleep Apnea.Current atherosclerosis reports · 2025Review
- Upper Airway Collapsibility During Rapid Eye Movement Sleep Is Associated With the Response to Upper Airway Surgery for Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2025Article
- The impact of obesity on upper airway anatomy as assessed by magnetic resonance imaging and obstructive sleep apnea endotypic traits.Frontiers in physiology · 2025Article
- The Association of Body Mass Index and Adiposity-Estimating Equations with Measures of Obstructive Sleep Apnea Severity: A Cross-Sectional Study.Nature and science of sleep · 2025Article
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6 authors.
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Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is more prevalent in men and older adults. Few studies have explored variations in pathological endotypic traits by age and sex using a large patient sample, offering insights into the development of the disease. Our study aims to examine how endotype characteristics of OSA vary across ages in different sex.
methodsA cross-sectional study was conducted, enrolling 2296 adult patients referred for in-laboratory diagnostic polysomnography at a single sleep center in Taiwan. Among them, 1374 had an apnea-hypopnea index ≥5. Using the "Phenotyping Using Polysomnography" method, we estimated four endotypic traits-arousal threshold, upper airway collapsibility, loop gain, and upper airway muscle compensation. Demographic and polysomnographic characteristics were compared between sexes and age groups. Generalized linear regression and generalized additive models were employed to explore the associations of sex and age with endotypic traits.
resultsMen with OSA exhibited higher collapsibility and lower compensation than women (difference: 4.32 %eupnea and 4.49 %eupnea, respectively). Younger patients with OSA had a higher prevalence of obesity, more snoring symptoms, and lower loop gain compared to older patients. For men, age was correlated with increased collapsibility, increased loop gain, and decreased arousal threshold after 37 years old. Whereas in women, endotypic traits were not associated with age, except for an increase in loop gain with advancing age.
conclusionsPersonalized treatment options for OSA should take into consideration age and sex. Reducing loop gain could be a treatment objective for older patients with OSA.
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