Evidence map›Paper›PMID 39127870›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Chronic ethanol exposure decreases H3K27me3 in the Il6 promoter region of macrophages and generates persistent dysfunction on neutrophils during fungal infection.

Flávia Rayssa Braga Martins, Vinicius Amorim Beltrami, Isabelle Cruz Zenóbio, Débora Gonzaga Martins, Isabella Luísa da Silva Gurgel, Naiara de Assis Rabelo Ribeiro, Celso Martins Queiroz-Junior, Daniella Bonaventura, Barbara Maximino Rezende, Mauro Martins Teixeira and 3 more

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Alcohol's Effects on the Lung and Lung Disease.Alcohol research : current reviews · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Flávia Rayssa Braga MartinsDepartment of Genetics, Ecology, and Evolution, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vinicius Amorim BeltramiDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Isabelle Cruz ZenóbioDepartment of Genetics, Ecology, and Evolution, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Débora Gonzaga MartinsDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Isabella Luísa da Silva GurgelDepartment of Genetics, Ecology, and Evolution, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Naiara de Assis Rabelo RibeiroDepartment of Pharmacology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Celso Martins Queiroz-JuniorDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Daniella BonaventuraDepartment of Pharmacology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Barbara Maximino RezendeDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mauro Martins TeixeiraDepartment of Biochemistry and Immunology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vanessa PinhoDepartment of Morphology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Nathalia Luisa OliveiraDepartment of Genetics, Ecology, and Evolution, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Frederico Marianetti SorianiDepartment of Genetics, Ecology, and Evolution, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, Brazil. fredsori@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308776/2021-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-03950-17; APQ-01899-18; 38/2022; APQ-00728-21
6 · The paper itself

Abstract

OBJECTIVE AND

designThe aim of this study was to investigate the effects of ethanol exposure on epigenetic markers in bone marrow (BM) and their impact on inflammatory response during Aspergillus fumigatus infection.

resultsChronic ethanol exposure decreased H3K27me3 enrichment in the Il6 promoter region while increased H3K4me3 enrichment in Tnf. Chimeric mice were generated by transplanting BM from mice exposed to ethanol or water. Infection of ethanol-chimeric mice culminated in higher clinical scores, although there was no effect on mortality. However, previous chronic exposure to ethanol affects persistently the inflammatory response in lung tissue, demonstrated by increased lung damage, neutrophil accumulation and IL-6, TNF and CXCL2 production in ethanol-chimeric mice, resulting in a decreased neutrophil infiltration into the alveolar space. Neutrophil killing and phagocytosis were also significantly lower. Moreover, BM derived macrophages (BMDM) from ethanol-chimeric mice stimulated with A. fumigatus conidia exhibited higher levels of TNF, CXCL2 and IL-6 release and a higher killing activity. The Il6 promoter of BMDM from ethanol-chimeric mice exhibited a reduction in H3K27me3 enrichment, a finding also observed in BM donors exposed to ethanol.

conclusionsThese evidences demonstrate that prior chronic alcohol exposure of bone-marrow modify immune effector cells functions impairing the inflammatory response during A. fumigatus infection. These findings highlight the persistent impact of chronic ethanol exposure on infectious disease outcomes.

Indexed as

AspergillosisAspergillus fumigatusEthanolHistonesInterleukin-6MacrophagesNeutrophilsPromoter Regions, GeneticAnimalsChemokine CXCL2LungMaleMiceMice, Inbred C57BLPhagocytosisTumor Necrosis Factor-alphaChemokine CXCL2EthanolHistonesInterleukin-6Tumor Necrosis Factor-alphaAlcoholAspergillosisEpigeneticInflammation

Identifiers

PMID39127870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.