Evidence map›Paper›PMID 39127857›Full record

ArticleIrish journal of medical science2024

Serum fibulin-3 as a diagnostic and prognostic biomarker in patients with knee osteoarthritis.

Maria Abdullah Hassan, Areej Sh Hameed, Ekhlas Khalid Hameed

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Article in Irish journal of medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Maria Abdullah HassanBiochemistry Department, College of Science for Women ,University of Baghdad, Baghdad, Iraq.ORCID http://orcid.org/0009-0003-6853-7859
Areej Sh HameedBiochemistry Department, College of Science for Women ,University of Baghdad, Baghdad, Iraq.ORCID http://orcid.org/0000-0002-7268-3141
Ekhlas Khalid HameedClinical Biochemistry Department, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq. ikhlaskhalid@kmc.uobaghdad.edu.iq.ORCID http://orcid.org/0000-0002-0068-3329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoarthritis is a chronic degenerative disorder with rising prevalence. Early detection of structural damage is difficult. Consequently, there is a pressing demand for reliable biomarkers that enable an earlier diagnosis of osteoarthritis. The aim is to investigate the level of serum fibulin-3 in patients with primary knee osteoarthritis and its correlation with disease severity. SUBJECTS AND

methodsA case-control study was conducted at the Baqubah Teaching Hospital from November 2023 to January 2024. One hundred twenty persons participated in this study (eighty females with the diagnosis of knee osteoarthritis in its early and late stages, and forty age-matched, apparently healthy control. Serum fibulin-3, ESR, CRP, and calcium levels were measured for all participants. Ethical approval was obtained. SPSS was used for data analysis.

resultsPatients with osteoarthritis had considerably higher serum levels of fibulin-3. In patients with late-stage knee osteoarthritis, this rise was greater than in earlier stages. Serum fibulin and ESR are positively correlated. Fibulin's area under the curve is 0.830 for diagnosis and 0.709 for differentiating between osteoarthritis's early and late stages.

conclusionSerum levels of fibulin-3 can act as diagnostic markers for OA and may be useful in determining the severity of knee osteoarthritis.

Indexed as

BiomarkersExtracellular Matrix ProteinsOsteoarthritis, KneeAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPrognosisSeverity of Illness IndexBiomarkersEFEMP1 protein, humanExtracellular Matrix ProteinsBiomarkerFibulinKnee osteoarthritis

Identifiers

PMID39127857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.