Evidence map›Paper›PMID 39127844›Full record

ArticleDigestive diseases and sciences2024

Validation of a Hand-Held Point-of-Care Device to Measure Breath Hydrogen and Its Utility in Detecting Response to Antibiotic Treatment.

Guillermo Barahona, Barry Mc Bride, Áine Moran, Ricky Harrison, Luisa Villatoro, Robert Burns, Bo Konings, Robert Bulat, Megan McKnight, Glenn Treisman and 1 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guillermo BarahonaJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Barry Mc BrideFoodMarble Digestive Health, Dublin, Ireland.
Áine MoranFoodMarble Digestive Health, Dublin, Ireland.
Ricky HarrisonFoodMarble Digestive Health, Dublin, Ireland.
Luisa VillatoroJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Robert BurnsJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Bo KoningsJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Robert BulatJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Megan McKnightJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Glenn TreismanDepartment of Psychiatry and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pankaj J PasrichaJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA. pasricha.jay@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreath testing for small intestinal bacterial overgrowth (SIBO) is typically performed using clinic-based equipment or single-use test kits.

aimsThis study aimed to evaluate the utility of a portable, point-of-care breath analysis device (AIRE®, FoodMarble) in patients suspected to have SIBO. A technical assessment including a comparison to existing mail-in kits was first performed. Then, postprandial breath hydrogen levels of patients before and after antibiotic treatment were gathered and compared to levels seen in a healthy cohort.

methodsFor the comparison, 50 patients suspected of having SIBO were provided with an AIRE device and performed concurrent LHBTs at-home with a mail-in breath test kit. For the postprandial analysis, twenty-four patients with chronic GI symptoms measured their postprandial hydrogen for 7 days prior to antibiotic treatment and for 7 days after treatment. 10 healthy controls also measured their postprandial hydrogen for 7 days.

resultsSubstantial agreement was demonstrated between AIRE and the mail-in kits for the performance of lactulose hydrogen breath tests (κ = 0.8). Prior to treatment, patients had significantly greater daily postprandial hydrogen than healthy controls (p < 0.001). The mean postprandial hydrogen of patients reduced significantly after treatment (p < 0.001).

conclusionsMeasuring postprandial hydrogen shows potential as a means of differentiating patients with chronic GI symptoms from healthy controls and may be useful in monitoring patients before, during, and after treatment. Future studies could help determine if pre-treatment breath gas levels are predictive of response to antibiotic treatment.

Indexed as

Anti-Bacterial AgentsBreath TestsHydrogenPoint-of-Care SystemsAdultAgedBlind Loop SyndromeCase-Control StudiesFemaleHumansMaleMiddle AgedPoint-of-Care TestingAnti-Bacterial AgentsHydrogenDigital healthPersonal breath test devicePostprandial breath hydrogenRemote patient monitoringRemote testing

Identifiers

PMID39127844
PMCPMC11602852

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.