Evidence map›Paper›PMID 39127819›Full record

ArticleEndocrine2025

Assessment of small nerve fiber function as an early marker of peripheral neuropathy in children and adolescents with type 1 diabetes mellitus (T1DM).

Argyropoulou Stavroula, Kokotis Panagiotis, Paltoglou George, Boutziouka Chrysanthi, Karamatzianni Georgia, Karanasios Spyridon, Sakou Irine-Ikbale, Karavanaki Kyriaki

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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Argyropoulou StavroulaDiabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Childrens Hospital, Athens, Greece.
Kokotis PanagiotisLaboratory of Clinical Neurophysiology, First Department of Neurology, National and Kapodistrian University of Athens, "Aeginitio" University Hospital, Athens, Greece.
Paltoglou GeorgeDiabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Childrens Hospital, Athens, Greece. gpaltoglou@med.uoa.gr.
Boutziouka ChrysanthiLaboratory of Clinical Neurophysiology, First Department of Neurology, National and Kapodistrian University of Athens, "Aeginitio" University Hospital, Athens, Greece.
Karamatzianni GeorgiaLaboratory of Clinical Neurophysiology, First Department of Neurology, National and Kapodistrian University of Athens, "Aeginitio" University Hospital, Athens, Greece.
Karanasios SpyridonDiabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Childrens Hospital, Athens, Greece.
Sakou Irine-IkbaleDiabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Childrens Hospital, Athens, Greece.
Karavanaki KyriakiDiabetes and Metabolism Unit, 2nd Department of Pediatrics, National and Kapodistrian University of Athens, "P&A Kyriakou" Childrens Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to assess subclinical peripheral diabetic neuropathy (PDN) in adolescents with type 1 diabetes mellitus (T1DM).

methodsSubjects included 53 T1DM patients (age (mean ± SE): 15.8 ± 0.54 years, disease duration: 6.0 ± 0.51 years and HbA1c: 7.9 ± 0.19%), and 37 healthy gender matched controls (age: 15.6 ± 0.52 years). PDN was assessed by vibration perception threshold (VPT) and by quantitative sensory testing (QST). In controls, 95% confidence intervals were calculated.

resultsAmong patients, VPT prevalence of abnormality ranged from 60-73.4% on different sites. Higher VPT was found in patients on all examined sites (p < 0.01). In controls, VPT correlated with height (r = 0.48, p = 0.05). Regarding QST prevalence of abnormality, cold detection threshold (CDT) ranged 7.3-39.0%, cold pain threshold (CPT) ranged 22.22-29.63%, hot detection threshold (HDT) ranged 34.14-63.41%, and hot pain threshold (HPT) ranged 15.79-36.84%. In patients, CPT correlated with BMI (r = 0.42, p = 0.05) and diabetes duration, (r = 0.40, p = 0.05), HPT correlated with age (r = 0.36, p = 0.05) and height (r = 0.35, p = 0.05), while in controls with BMI (r = 0.51, p = 0.05). No correlation of VPT or QST with HbA1c was observed.

conclusionAdolescents with T1DM in this study, although asymptomatic, showed a high prevalence of impaired indices of PDN, highlighting potential clinical implications of early identification of PDN.

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesNerve FibersAdolescentBiomarkersCase-Control StudiesChildEarly DiagnosisFemaleHumansMalePain ThresholdSensory ThresholdsBiomarkersPediatric type 1 diabetes mellitusPeripheral diabetic neuropathyQuantitative sensory testingSmall nerve fiber neuropathyVibration perception threshold

Identifiers

PMID39127819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.