Evidence map›Paper›PMID 39127702›Full record

ArticleBMC research notes2024

Effects of HTLV-1 on leukocyte trafficking and migration in ACs compared to healthy individuals.

Arash Letafati, Atefeh Bahavar, Mehdi Norouzi, Aziz Rasouli, Mojtaba Hedayatyaghoubi, Ghazale Molaverdi, Sayed-Hamidreza Mozhgani, Zeinab Siami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arash LetafatiDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Atefeh BahavarDepartment of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Mehdi NorouziDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Aziz RasouliDepartment of Emergency Medicine, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mojtaba HedayatyaghoubiDepartment of Infectious Diseases, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Ghazale MolaverdiStudent Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Sayed-Hamidreza MozhganiNon-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran. hamidrezamozhgani@gmail.com.
Zeinab SiamiDepartment of Infectious Diseases, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran. siami_z@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) is a RNA virus belonging to Retroviridae family and is associated with the development of various diseases, including adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Aside from HAM/TSP, HTLV-1 has been implicated in the development of several disorders that mimic auto-inflammation. T-cell migration is important topic in the context of HTLV-1 associated diseases progression. The primary objective of this case-control study was to assess the relationship between increased mRNA expression in virus migration following HTLV-1 infection. PBMCs from 20 asymptomatic patients and 20 healthy subjects were analyzed using real-time PCR to measure mRNA expression of LFA1, MLCK, RAC1, RAPL, ROCK1, VAV1 and CXCR4. Also, mRNA expression of Tax and HBZ were evaluated. Mean expression of Tax and HBZ in ACs (asymptomatic carriers) was 0.7218 and 0.6517 respectively. The results revealed a noteworthy upregulation of these genes involved in T-cell migration among ACs patients in comparison to healthy individuals. Considering the pivotal role of gene expression alterations associated with the progression into two major diseases (ATLL or HAM/TSP), analyzing the expression of these genes in the ACs group can offer probable potential diagnostic markers and aid in monitoring the condition of ACs.

Indexed as

Cell MovementHTLV-I InfectionsHuman T-lymphotropic virus 1AdultBasic-Leucine Zipper Transcription FactorsCase-Control StudiesFemaleGene Products, taxHumansLeukocytesLymphocyte Function-Associated Antigen-1MaleMiddle AgedProto-Oncogene Proteins c-vavReceptors, CXCR4Retroviridae ProteinsBasic-Leucine Zipper Transcription FactorsCXCR4 protein, humanGene Products, taxHBZ protein, human T-cell leukemia virus type ILymphocyte Function-Associated Antigen-1Proto-Oncogene Proteins c-vavReceptors, CXCR4Retroviridae Proteinsrho-Associated KinasesRNA, MessengerROCK1 protein, humantax protein, Human T-lymphotrophic virus 1VAV1 protein, humanACsATLLCell migrationHAM/TSPHTLV-1MRNA expression

Identifiers

PMID39127702
PMCPMC11316973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.