Evidence map›Paper›PMID 39127673›Full record

ArticleBMC pediatrics2024

Prevalence, patterns, and factors associated with abnormal lung function among children with sickle cell disease in Uganda: a cross-sectional study.

Pamella Mwa Aol, Geriga Fahdil, Felix Bongomin, Bonny Okello, Charles Batte, Bruce J Kirenga, Rebecca Nantanda, Hellen Tukamuhebwa Aanyu

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pamella Mwa AolDepartment of Paediatrics and Child Health, St. Mary's Hospital Lacor, Gulu, Uganda.
Geriga FahdilUganda Cancer Institute, Mulago National Referral Hospital, Kampala, Uganda.
Felix BongominDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Bonny OkelloDepartment of Planning, Kwania District Local Government, Kwania, Uganda.
Charles BatteCollege of Health Sciences, Makerere University Lung Institute, Makerere University Kampala, Kampala, Uganda.
Bruce J KirengaCollege of Health Sciences, Makerere University Lung Institute, Makerere University Kampala, Kampala, Uganda.
Rebecca NantandaCollege of Health Sciences, Makerere University Lung Institute, Makerere University Kampala, Kampala, Uganda. rnantanda@gmail.com.
Hellen Tukamuhebwa AanyuDepartment of Paediatrics and Child Health, Mulago National Referral Hospital, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary complications are common among children with sickle cell disease (SCD). However, there is little literature on associated lung function abnormalities in Uganda. We aimed to determine the prevalence, patterns, and factors associated with abnormal lung function among children with SCD in a tertiary care hospital in Uganda.

methodA cross-sectional study was conducted among children aged 6 to 18 years at the SCD clinic (SCC) of Mulago National Super-Specialized Hospital between January 2020 and April 2021. Data on sociodemographic and clinical characteristics was collected using a standardized questionnaire. Laboratory investigations, including a complete blood count and serum lactate dehydrogenase (LDH), were done. Spirometry was performed following the ATS/ERS standards. Multivariable modified Poisson regression analysis was performed to determine factors associated with abnormal lung function.

resultsA total of 332 participants were enrolled. The mean age was 11.7 ± 3.4 years, and 184 (55.4%) were female. Overall, 126 (37.9%) participants had abnormal lung function: 67/126 (53.2%) restrictive, 57/126 (45.2%) obstructive, and 2/126 (1.6%) mixed-ventilatory patterns. Factors associated with abnormal lung function were; serum LDH level > 600UL (aIRR: 1.89 95% CI: 1.2 - 7.4, p = 0.049), a history of acute chest syndrome (aIRR: 1.55, 95% CI: 1.06-2.25, p = 0.024), wasting (aIRR: 1.33, 95%CI: 1.02 - 1.72, p = 0.032), and use of charcoal for household cooking (aIRR: 1.49, 95% CI: 1.03-2.15, p = 0.035).

conclusionMore than one-third of children with SCD in Uganda have lung function abnormalities. Strategies to improve nutrition, reduce exposure to charcoal smoke, and monitoring serum LDH levels may be important in preventing or managing abnormal lung function in this population. The identification of reversible and irreversible airway obstruction in children with sickle cell disease also highlights the need for targeted interventions to address these specific patterns of abnormal lung function.

Indexed as

Anemia, Sickle CellAdolescentChildCross-Sectional StudiesFemaleHumansLung DiseasesMalePrevalenceRespiratory Function TestsRisk FactorsSpirometryUgandaChildrenLung functionSickle cell diseaseUganda

Identifiers

PMID39127673
PMCPMC11316324

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.