Evidence map›Paper›PMID 39127645›Full record

ArticleBMC microbiology2024

The Velvet transcription factor PnVeA regulates necrotrophic effectors and secondary metabolism in the wheat pathogen Parastagonospora nodorum.

Shota Morikawa, Callum Verdonk, Evan John, Leon Lenzo, Nicolau Sbaraini, Chala Turo, Hang Li, David Jiang, Yit-Heng Chooi, Kar-Chun Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shota MorikawaCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Callum VerdonkCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Evan JohnCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Leon LenzoCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Nicolau SbarainiSchool of Molecular Sciences, University of Western Australia, Perth, Australia.
Chala TuroCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Hang LiSchool of Molecular Sciences, University of Western Australia, Perth, Australia.
David JiangCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia.
Yit-Heng ChooiSchool of Molecular Sciences, University of Western Australia, Perth, Australia.
Kar-Chun TanCentre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia. Kar-Chun.Tan@curtin.edu.au.

Funding

Curtin University of Technology CUR00023Grains Research and Development Corporation CUR00023
6 · The paper itself

Abstract

The fungus Parastagonospora nodorum causes septoria nodorum blotch on wheat. The role of the fungal Velvet-family transcription factor VeA in P. nodorum development and virulence was investigated here. Deletion of the P. nodorum VeA ortholog, PnVeA, resulted in growth abnormalities including pigmentation, abolished asexual sporulation and highly reduced virulence on wheat. Comparative RNA-Seq and RT-PCR analyses revealed that the deletion of PnVeA also decoupled the expression of major necrotrophic effector genes. In addition, the deletion of PnVeA resulted in an up-regulation of four predicted secondary metabolite (SM) gene clusters. Using liquid-chromatography mass-spectrometry, it was observed that one of the SM gene clusters led to an accumulation of the mycotoxin alternariol. PnVeA is essential for asexual sporulation, full virulence, secondary metabolism and necrotrophic effector regulation.

Indexed as

AscomycotaFungal ProteinsPlant DiseasesSecondary MetabolismTranscription FactorsTriticumGene Expression Regulation, FungalLactonesMultigene FamilyMycotoxinsSpores, FungalVirulencealternariolFungal ProteinsLactonesMycotoxinsTranscription FactorsNecrotrophic effectorParastagonospora nodorumSecondary metaboliteVelvet AWheat

Identifiers

PMID39127645
PMCPMC11316297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.