ArticleExperimental eye research2024
Dynasore modulates store-operated calcium entry and mitochondrial calcium release in corneal epithelial cells.
Rafael Martínez-Carrasco, M Elizabeth Fini
Abstract read
In one paragraphArticle in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
2 authors.
Rafael Martínez-CarrascoNew England Eye Center, Tufts Medical Center and Department of Ophthalmology, Tufts University School of Medicine, 800 Washington St, Boston, MA, 02111, USA.
M Elizabeth FiniNew England Eye Center, Tufts Medical Center and Department of Ophthalmology, Tufts University School of Medicine, 800 Washington St, Boston, MA, 02111, USA; Program in Genetics, Molecular & Cellular Biology, Tufts Graduate School of Biomedical Sciences, Tufts University, 136 Harrison Ave, Boston, MA, USA; Program in Pharmacology & Drug Development, Tufts Graduate School of Biomedical Sciences, 136 Harrison Ave, Tufts University, Boston, MA, USA. Electronic address: elizabeth.fini@tuftsmedicine.org.
Funding
Clusterin at the Ocular Surface Administrative Supplement IIR01EY026479 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINI, M ELIZABETH · 2016 to 2020
$2.9MMETALLOPROTEINASES AND FAILURE TO REEPITHELIALIZER01EY012651 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FINI, M. ELIZABETH · 1999 to 2006
$2.5MMitochondria and Mustard Damage at the Ocular SurfaceR01EY035220 · NEI · TUFTS MEDICAL CENTER · PI FINI, M ELIZABETH · 2023 to 2025
$1.6MDynasore Analogues for Ocular Surface ProtectionR41EY030811 · NEI · MEDCHEM PARTNERS, LLC · PI FINI, M ELIZABETH, LAZAROVA, TSVETELINA IVANONOVA · 2019 to 2021
$556kCombating Corneal HSV Infection with Novel Dynasore AnaloguesR41EY035879 · NEI · MEDCHEM PARTNERS, LLC · PI LAZAROVA, TSVETELINA IVANONOVA, ST LEGER, ANTHONY J · 2024 to 2025
$359kNEI NIH HHS R01 EY012651NEI NIH HHS R01 EY026479NEI NIH HHS R01 EY035220NEI NIH HHS R41 EY030811NEI NIH HHS R41 EY035879
6 · The paper itselfAbstract
Dysregulation of calcium homeostasis can precipitate a cascade of pathological events that lead to tissue damage and cell death. Dynasore is a small molecule that inhibits endocytosis by targeting classic dynamins. In a previous study, we showed that dynasore can protect human corneal epithelial cells from damage due to tert-butyl hydroperoxide (tBHP) exposure by restoring cellular calcium (Ca
Indexed as
CalciumEpithelium, CornealHydrazonesMitochondriaCalcium ChannelsCalcium SignalingCells, CulturedEndoplasmic ReticulumHomeostasisHumanstert-ButylhydroperoxideThapsigarginCalciumCalcium ChannelsHydrazonestert-ButylhydroperoxideThapsigarginCalciumCorneaDynasoreEndocytosisEpithelial cellHomeostasisMitochondriaOxidative stress
Identifiers
PMID39127237
PMCPMC11413707
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