Evidence map›Paper›PMID 39126571›Full record

ArticleInflammopharmacology2024

Fixed oil from the Caatinga palm Syagrus coronata with effect on Complete Freund's Adjuvant (CFA)-induced arthritis.

João Victor de Oliveira Alves, Bartira Victoria Dantas da Rocha Barbosa, Irivânia Fidelis da Silva Aguiar, Laís Ruanita Leopoldina Galvão, Rafael Jardim Ferreira, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Maria Tereza Dos Santos Correia and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Licuri Oil (Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

João Victor de Oliveira AlvesDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Bartira Victoria Dantas da Rocha BarbosaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Irivânia Fidelis da Silva AguiarDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Laís Ruanita Leopoldina GalvãoDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Rafael Jardim FerreiraFaculdade de Odontologia, Universidade de Pernambuco, Camaragibe, PE, 54756-220, Brazil.
Julliano Matheus de Lima MauxLaboratório de Pesquisa Citológicas E Moleculares, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Jacinto da Costa Silva NetoLaboratório de Pesquisa Citológicas E Moleculares, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Alisson Macário de OliveiraDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Thiago Henrique NapoleãoDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Maria Tereza Dos Santos CorreiaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Wêndeo Kennedy CostaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil. wendeocosta@gmail.com.ORCID http://orcid.org/0000-0001-7925-6794
Marcia Vanusa da SilvaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.

Funding

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco BFP-0038-2.08/23
6 · The paper itself

Abstract

Syagrus coronata, a native palm tree in the Caatinga domain, produces fixed oil (ScFO) used therapeutically and dietary by Northeast Brazilian communities. This study evaluated its anti-inflammatory potential of CFA-induced arthritis and its effect on behavioral parameters. In the acute model, ScFO at 25, 50, and 100 mg/kg showed edematogenic effects similar to indomethacin at 4 mg/kg (p > 0.05). In the arthritis model, 100 mg/kg ScFO treatment was comparable to indomethacin (4 mg/kg) (p > 0.05). TNF-α and IL-1β levels were significantly reduced in ScFO-treated groups at 25, 50, and 100 mg/kg, and the indomethacin group (4 mg/kg) versus the positive control (p > 0.05). Radiographs showed severe soft-tissue swelling and bone deformities in the control group, while the 100 mg/kg ScFO group had few alterations, similar to the indomethacin group. Histopathological analysis revealed intense lymphocytic infiltration in the control group, mild diffuse lymphocytic infiltration in the indomethacin group, and mild lymphoplasmacytic infiltration with focal polymorphonuclear infiltrates in the 100 mg/kg ScFO group. Behavioral analysis showed improved exploratory stimuli in ScFO and indomethacin-treated mice compared to the positive control (p > 0.05). ScFO demonstrated anti-inflammatory effects in both acute and chronic arthritis models, reducing edema and pro-inflammatory cytokines, and improved exploratory behavior due to its analgesic properties.

Indexed as

Anti-Inflammatory AgentsArthritis, ExperimentalFreund's AdjuvantAnimalsArecaceaeBrazilDose-Response Relationship, DrugEdemaIndomethacinInterleukin-1betaMaleMicePalm OilPlant OilsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsFreund's AdjuvantIndomethacinInterleukin-1betaPalm OilPlant OilsTumor Necrosis Factor-alphaAntiarthriticAnti-inflammatoryCaatingaCytokinesInflammation

Identifiers

PMID39126571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.