Evidence map›Paper›PMID 39126570›Full record

SynthesisInflammopharmacology2024

Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

Túlio Pimentel, Ivo Queiroz, Cynthia Florêncio de Mesquita, Mariano Gallo Ruelas, Giovanna N Leandro, Arthur Ribeiro Monteiro, Fernando Nunes Pimentel

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Túlio PimentelFederal University of Pernambuco, Recife, Brazil. tulio.pimentel@ufpe.br.ORCID http://orcid.org/0009-0000-1913-9465
Ivo QueirozCatholic University of Pernambuco, Recife, Brazil.ORCID http://orcid.org/0009-0001-6544-8450
Cynthia Florêncio de MesquitaFederal University of Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0002-4146-2098
Mariano Gallo RuelasInstituto de Investigación Nutricional (IIN), Lima, Peru.ORCID http://orcid.org/0000-0003-1484-4581
Giovanna N LeandroFederal University of Pernambuco, Recife, Brazil.ORCID http://orcid.org/0000-0001-7545-1111
Arthur Ribeiro MonteiroFederal University of Pernambuco, Recife, Brazil.ORCID http://orcid.org/0009-0001-0265-4919
Fernando Nunes PimentelClínica Reumatológica Fernando Pimentel, Recife, Brazil.ORCID http://orcid.org/0000-0002-1127-9495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKnee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonsteroidal anti-inflammatory drugs and analgesics, often lead to adverse effects. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.

methodsMEDLINE, Embase, and Cochrane databases were searched until May 2024 for studies comparing krill oil and placebo in knee pain patients. Endpoints included knee pain, stiffness, physical function, and lipid profiles (HDL-C, LDL-C, triglycerides, and total cholesterol). A restricted maximum likelihood random-effects model with standardized mean differences (SMD) and 95% confidence intervals (CI) was used. A trial sequential analysis was conducted to evaluate further research implications.

resultsWe included five trials with 700 patients using krill oil for knee pain. Results showed no significant difference between krill oil and placebo for knee pain, knee stiffness, and lipid profiles. However, krill oil demonstrated a significant small effect in improving knee physical function (SMD -0.24, 95% CI [-0.41; -0.08], I

conclusionThis study found that krill oil supplementation did not significantly improve knee pain, stiffness, or lipid profile, although it may help knee physical function. Based on these findings, krill oil supplementation is not yet justified for knee pain.

Indexed as

ArthralgiaDietary SupplementsEuphausiaceaOilsAnimalsHumansKnee JointRandomized Controlled Trials as TopicOilsKnee painKrill oilPhysical functionSupplementation

Identifiers

PMID39126570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.