Evidence map›Paper›PMID 39126567›Full record

ReviewInflammopharmacology2024

Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases.

Hang Han, Guojiang Zhang, Xiao Zhang, Qinjian Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Effects of Acrylamide on Mouse Implantation and Decidualization.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hang HanCollege of Pharmacy, Chongqing Medical University, Chongqing, Chongqing, 400016, China.
Guojiang ZhangCollege of Pharmacy, Chongqing Medical University, Chongqing, Chongqing, 400016, China.
Xiao ZhangCollege of Pharmacy, Chongqing Medical University, Chongqing, Chongqing, 400016, China. zhangxiao@cqmu.edu.cn.ORCID http://orcid.org/0000-0001-6655-2463
Qinjian ZhaoCollege of Pharmacy, Chongqing Medical University, Chongqing, Chongqing, 400016, China. zhaoqinjian@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-6297-9969

Funding

Chongqing Education Commission of Science and Technology Research Project KJQN202300453National Natural Science Foundation of China 32070925National Natural Science Foundation of China 82371832Natural Science Foundation of Chongqing City 2023NSCQ-MSX1536Natural Science Foundation of Fujian Province 2023J011235
6 · The paper itself

Abstract

Inflammatory diseases, including psoriasis, atherosclerosis, rheumatoid arthritis, and ulcerative colitis, are characterized by persistent inflammation. Moreover, the existing treatments for inflammatory diseases only provide temporary relief by controlling symptoms, and treatments of unstable and expensive. Therefore, new therapeutic solutions are urgently needed to address the underlying causes or symptoms of inflammatory diseases. Inflammation frequently coincides with a high level of (reactive oxygen species) ROS activation, serving as a fundamental element in numerous physiological and pathological phenotypes that can result in serious harm to the organism. Given its pivotal role in inflammation, oxidative stress, and ferroptosis, ROS represents a focal node for investigating the (nuclear factor E2-related factor 2) Nrf2 pathway and ferroptosis, both of which are intricately linked to ROS. Ferroptosis is mainly triggered by oxidative stress and involves iron-dependent lipid peroxidation. The transcription factor Nrf2 targets several genes within the ferroptosis pathway. Recent studies have shown that Nrf2 plays a significant role in three key ferroptosis-related routes, including the synthesis and metabolism of glutathione/glutathione peroxidase 4, iron metabolism, and lipid processes. As a result, ferroptosis-related treatments for inflammatory diseases have attracted much attention. Moreover, drugs targeting Nrf2 can be used to manage inflammatory conditions. This review aimed to assess ferroptosis regulation mechanism and the role of Nrf2 in ferroptosis inhibition. Therefore, this review article may provide the basis for more research regarding the treatment of inflammatory diseases through Nrf2-inhibited ferroptosis.

Indexed as

FerroptosisInflammationNF-E2-Related Factor 2AnimalsAnti-Inflammatory AgentsHumansOxidative StressReactive Oxygen SpeciesAnti-Inflammatory AgentsNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesFerroptosisInflammatory diseasesNrf2Nrf2 activatorsOxidative stressROS

Identifiers

PMID39126567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.