Evidence map›Paper›PMID 39126541›Full record

ArticleBulletin of experimental biology and medicine2024

Level of Cytokines and C3 Complement in the Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Durations.

D V Skripkina, A Yu Abramova, B B Shoibonov, I V Alekseeva, E V Nikenina, S S Pertsov

Abstract read
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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D V SkripkinaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. dashaskripkina@yandex.ru.
A Yu AbramovaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
B B ShoibonovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
I V AlekseevaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
E V NikeninaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
S S PertsovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamics of observation, a general tendency towards multidirectional fluctuations in the concentration of cytokines was revealed: an increase in IL-10, but a decrease in IL-4 in comparison with the control. Statistically significant changes in the level of IL-10 were noted after 2, 3, and 4 weeks, IL-4 - after 2 and 4 weeks of stress loads. The percentage of lysis of the C3 component in rats gradually increased by the 2nd week of chronic stress, but then decreased and practically did not differ from the control values (intact animals) by the end of the study. These results illustrate the specificity of changes in the indicators of the C component of the complement system and the cytokine profile of the blood reflecting activity of the cellular and humoral components of the immune response in rats exposed to repeated stress factors of different origins and duration.

Indexed as

Complement C3Interleukin-10Interleukin-4Stress, PsychologicalAnimalsCytokinesMaleRatsRats, WistarStress, PhysiologicalComplement C3CytokinesInterleukin-10Interleukin-4blood cytokinesC3 component of complement systemchronic unpredictable mild stressrats

Identifiers

PMID39126541

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.