Evidence map›Paper›PMID 39126435›Full record

ArticleJournal of applied genetics2025

Short communication: catechol-O-methyltransferase allelic variation in relation to psychological and hormonal indices of stress in children and adolescents with chromosome 22q11.2 deletion syndrome (22q11.2DS).

Jessie L Beebe, Cydney R Martin, Ashley F P Sanders, Jeremy Guidry, Fahad Faheem, Joel Atallah, Elliott A Beaton

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Article in Journal of applied genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Jessie L BeebeDepartment of Biology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
Cydney R MartinDepartment of Biology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
Ashley F P SandersDepartment of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
Jeremy GuidryDepartment of Biology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
Fahad FaheemDepartment of Biology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA.
Joel AtallahDepartment of Biology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA. jatallah@uno.edu.ORCID http://orcid.org/0000-0003-2425-2395
Elliott A BeatonDepartment of Psychology, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA, 70148, USA. ebeaton@uno.edu.ORCID http://orcid.org/0000-0001-7631-4637

Funding

Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Physiological and neural indices of stress in children with 22q deletion syndromeR00MH086616 · NIMH · UNIVERSITY OF NEW ORLEANS · PI BEATON, ELLIOTT ALEXANDER · 2012 to 2014
$730k
Foundation for the National Institutes of Health 5R00MH086616-05NIMH NIH HHS R00 MH086616NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a developmental disorder with high rates of anxiety and psychosis. Catechol-O-methyltransferase (COMT) regulates epinephrine (E), norepinephrine (NE), and dopamine (DA) and is implicated in both anxiety and psychotic disorders. The aim of this study was to determine how COMT variation relates to psychological anxiety and associated stress physiology responsiveness to better understand symptom heterogeneity in people with 22q11.2DS. We examined COMT allelic variation in relation to anxiety and hypothalamic-pituitary-adrenocortical (HPA) and sympathetic-adrenomedullary (SAM) hormonal stress indicators in 30 children and adolescents with 22q11.2DS. Contrary to expectation, individuals with the higher activity COMTval allele had higher anxiety levels versus those with the low activity (COMTmet) allele (p = 0.021; Glass' Δ = 0.69). Anxiety was not correlated with salivary cortisol (CORT) or alpha-amylase (sAA) in either group. Groups did not differ in CORT levels (p = 0.58), but the COMTmet group had higher sAA (p = 0.026; Glass' Δ = 0.67, uncorrected) suggesting greater SAM reactivity but not HPA activity. This suggests that COMT allelic variation may contribute to differences in acute SAM but not slower HPA stress reactivity in those with 22q11.2DS.

Indexed as

Catechol O-MethyltransferaseDiGeorge SyndromeStress, PsychologicalAdolescentAllelesAnxietyChildFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleSalivaCatechol O-MethyltransferaseCOMT protein, humanHydrocortisone22q11.2DSAnxietyDiGeorge syndromeGeneticsNeurodevelopmental disorderVelocardiofacial syndrome

Identifiers

PMID39126435
PMCPMC12927469

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