Evidence map›Paper›PMID 39126219›Full record

ArticleCancer medicine2024

Influence of genetic co-mutation on chemotherapeutic outcome in NPM1-mutated and FLT3-ITD wild-type AML patients.

Quan Wu, Yujiao Zhang, Baoyi Yuan, Yun Huang, Ling Jiang, Fang Liu, Ping Yan, Jiaying Cheng, Zhiquan Long, Xuejie Jiang

Abstract read
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. AML, Myelodysplasia-Related: Beyond Classification-Toward Precision Decision-Making.Mediterranean journal of hematology and infectious diseases · 2026
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Quan WuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yujiao ZhangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Baoyi YuanDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yun HuangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ling JiangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Fang LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ping YanDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiaying ChengDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhiquan LongDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xuejie JiangDepartment of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0000-0002-0178-691X

Funding

National Natural Science Foundation of China 82170165Natural Science Foundation of Guangdong Province 2021A1515011437Natural Science Foundation of Guangdong Province 2023A1515012401
6 · The paper itself

Abstract

backgroundNucleophosmin 1 (NPM1) gene-mutated acute myeloid leukemia (NPM1

methodsIn this study, 91 NPM1-mutated and FLT3-ITD wild-type (NPM1

resultsOur data revealed that TET1/2 (52/91, 57.1%) was the most prevalent co-mutation in NPM1

conclusionMutations in TET1/2, GATA2 and MDS-related genes were found to significantly influence the chemotherapeutic outcome of patients with NPM1

Indexed as

fms-Like Tyrosine Kinase 3Leukemia, Myeloid, AcuteMutationNuclear ProteinsNucleophosminAdolescentAdultAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansMaleMiddle AgedPrognosisTreatment OutcomeYoung AdultFLT3 protein, humanfms-Like Tyrosine Kinase 3NPM1 protein, humanNuclear ProteinsNucleophosminacute myeloid leukemiachemotherapymolecular geneticssurvival

Identifiers

PMID39126219
PMCPMC11316012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.