Evidence map›Paper›PMID 39126158›Full record

ArticleNeuropsychopharmacology reports2024

Photopharmacological modulation of hippocampal local field potential by caged-glutamate with MicroLED probe.

Shogo Okada, Noriaki Ohkawa, Kazuki Moriya, Yoshito Saitoh, Mikiko Ishikawa, Kakeru Oya, Atsushi Nishikawa, Hiroto Sekiguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shogo OkadaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan.
Noriaki OhkawaDivision for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, Tochigi, Japan.ORCID 0000-0002-6754-9933
Kazuki MoriyaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan.
Yoshito SaitohDivision for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, Tochigi, Japan.
Mikiko IshikawaDivision for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, Tochigi, Japan.
Kakeru OyaDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan.
Atsushi NishikawaALLOS Semiconductors GmbH, Dresden, Sachsen, Germany.
Hiroto SekiguchiDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Toyohashi, Aichi, Japan.

Funding

Asahi Glass FoundationDaiko FoundationJapan Agency for Medical Research and Development Prime 23gm6510021h0001Japan Society for the Promotion of Science KAKENHI 23H01465Japan Society for the Promotion of Science KAKENHI 23H02789Japan Society for the Promotion of Science KAKENHI 23K18423Research Foundation for Opto-Science and TechnologyTakeda Science Foundation
6 · The paper itself

Abstract

aimPhotopharmacology is a new technique for modulating biological phenomena through the photoconversion of substances in a specific target region at precise times. Caged compounds are thought to be compatible with photopharmacology as uncaged ligands are released and function in a light irradiation-dependent manner. Here, we investigated whether a microscale light-emitting diode (MicroLED) probe is applicable for the photoconversion of caged-glutamate (caged-Glu) in vivo.

methodsA needle-shaped MicroLED probe was fabricated and inserted into the mouse hippocampal dentate gyrus (DG) with a cannula for drug injection and a recording electrode for measuring the local field potential (LFP). Artificial cerebrospinal fluid (ACSF) or caged-Glu was infused into the DG and illuminated with light from a MicroLED probe.

resultsIn the caged-Glu-injected DG, the LFP changed in the 10-20 Hz frequency ranges after light illumination, whereas there was no change in the ACSF control condition.

conclusionThe MicroLED probe is applicable for photopharmacological experiments to modulate LFP with caged-Glu in vivo.

Indexed as

Glutamic AcidHippocampusAnimalsDentate GyrusLightMaleMiceMice, Inbred C57BLGlutamic Acidcaged‐glutamatehippocampuslocal field potential (LFP)microscale light‐emitting diode (MicroLED)photopharmacology

Identifiers

PMID39126158
PMCPMC11544434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.