Evidence map›Paper›PMID 39126073›Full record

ArticleInternational journal of molecular sciences2024

Photoinactivation of

Nataliya V Kozobkova, Michael P Samtsov, Anatol P Lugovski, Nikita V Bel'ko, Dmitri S Tarasov, Arseny S Kaprelyants, Alexander P Savitsky, Margarita O Shleeva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nataliya V KozobkovaA.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0009-0006-8331-5818
Michael P SamtsovA.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus.ORCID 0000-0002-8392-7463
Anatol P LugovskiA.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus.ORCID 0000-0002-9609-5088
Nikita V Bel'koA.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus.
Dmitri S TarasovA.N. Sevchenko Institute of Applied Physical Problems of the Belarusian State University, 220045 Minsk, Belarus.ORCID 0000-0002-5008-5976
Arseny S KaprelyantsA.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.
Alexander P SavitskyA.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0002-6820-2341
Margarita O ShleevaA.N. Bach Institute of Biochemistry, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow 119071, Russia.

Funding

the Russian Science Foundation 24-15-00221
6 · The paper itself

Abstract

The spread of multidrug-resistant mycobacterium strains requires the development of new approaches to combat diseases caused by these pathogens. For that, photodynamic inactivation (PDI) is a promising approach. In this study, a tricarbocyanine (TCC) is used for the first time as a near-infrared (740 nm) activatable PDI photosensitizer to kill mycobacteria with deep light penetration. For better targeting, a novel tricarbocyanine dye functionalized with two trehalose units (TCC2Tre) is developed. The photodynamic effect of the conjugates against mycobacteria, including

Indexed as

Infrared RaysMycobacterium smegmatisMycobacterium tuberculosisPhotosensitizing AgentsTrehaloseCarbocyaninesPhotochemotherapyCarbocyaninesPhotosensitizing AgentsTrehaloseantibacterial photodynamic inactivationdormant mycobacteriamycobacteriaMycobacterium tuberculosistrehalosetricarbocyanine dye

Identifiers

PMID39126073
PMCPMC11313374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.