Evidence map›Paper›PMID 39125990›Full record

ArticleInternational journal of molecular sciences2024

New Amphiphilic Terpolymers of N-Vinylpyrrolidone with Acrylic Acid and Triethylene Glycol Dimethacrylate as Promising Drug Delivery: Design, Synthesis and Biological Properties In Vitro.

Svetlana V Kurmaz, Roman I Komendant, Evgenia O Perepelitsina, Vladimir A Kurmaz, Igor I Khodos, Nina S Emelyanova, Natalia V Filatova, Vera I Amozova, Anastasia A Balakina, Alexey A Terentyev

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Svetlana V KurmazFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0001-8269-8630
Roman I KomendantFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Evgenia O PerepelitsinaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Vladimir A KurmazFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0003-3967-9631
Igor I KhodosInstitute of Microelectronics Technology and High-Purity Materials, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0001-7574-0140
Nina S EmelyanovaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-0381-7695
Natalia V FilatovaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Vera I AmozovaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Anastasia A BalakinaFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Alexey A TerentyevFederal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-2259-8184

Funding

This work was funded by the Ministry of Science and Education of the Russian Federation No 124013000722-8, 124020500019-2 and 124013000692-4
6 · The paper itself

Abstract

The terpolymers of N-vinylpyrrolidone (VP) with acrylic acid and triethylene glycol methacrylate were synthesized with more than 90% yield by radical copolymerization in ethanol from monomeric mixtures of different molar composition (98:2:2, 95:5: 2 and 98:2:5) and their monomer composition, absolute molecular masses and hydrodynamic radii in aqueous media were determined. Using the MTT test, these terpolymers were established to be low toxic for non-tumor Vero cells and HeLa tumor cells. Polymer compositions of hydrophobic dye methyl pheophorbide a (MPP) based on studied terpolymers and linear polyvinylpyrrolidone (PVP) were obtained and characterized in water solution. Quantum-chemical modeling of the MPP-copolymer structures was conducted, and the possibility of hydrogen bond formation between terpolymer units and the MPP molecule was shown. Using fluorescence microscopy, the accumulation and distribution of polymer particles in non-tumor (FetMSC) and tumor (HeLa) cells was studied, and an increase in the accumulation of MPP with both types of particles was found.

Indexed as

AcrylatesAnimalsCell SurvivalChlorocebus aethiopsDrug Delivery SystemsHeLa CellsHumansMethacrylatesPolyethylene GlycolsPolymersPyrrolidinonesVero CellsAcrylatesacrylic acidMethacrylatesN-vinyl-2-pyrrolidinonePolyethylene GlycolsPolymersPyrrolidinonesacrylic acidamphiphilic terpolymersbiological activitycell accumulationfunctional compoundmedicinal chemistrymethylphemophide aN-vinylpyrrolidoneradical terpolymerizationtriethylene glycol dimethacrylate

Identifiers

PMID39125990
PMCPMC11312434

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