ArticleInternational journal of molecular sciences2024
Salivary IL-1β, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity.
Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory Mediators in the Oral Fluids and Blood Samples of Type 1 Diabetic Patients, According to Periodontal Status-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Clinical periodontal indices are associated with systemic inflammatory and oxidative stress biomarkers in dogs with periodontal disease.Veterinary and animal science · 2026Article
- Periodontal Indices and Cytokines of Ex-Smokers/Non-Smokers After Bleaching.Medicina (Kaunas, Lithuania) · 2026Article
- CB2 Receptor Activation Attenuates IL-1β-Induced Inflammatory Transcriptomic Networks in Human Gingival Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Assessment of Interleukin-6 (IL-6) and Cotinine Levels in the Saliva of Patients with Precancerous Lesions and Oral Mucosa Cancer.Journal of clinical medicine · 2026Article
- TAM pathway proteins as novel salivary biomarkers for periodontitis.Journal of periodontology · 2026Observational
- Salivary Cortisone as a Potential Alternative to Cortisol in Periodontitis Severity Assessment.International journal of molecular sciences · 2026Article
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Diabesity and Oral Immunity: Exploring the Interconnection.Advances in experimental medicine and biology · 2026Review
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
- Screening of Salivary Biomarkers of Bisphosphonate-Related Osteonecrosis of the Jaw in a Diabetic Rat Model.Current issues in molecular biology · 2025Article
- Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis.Clinical science (London, England : 1979) · 2025Review
- Salivary and Microbiome Biomarkers in Periodontitis: Advances in Diagnosis and Therapy-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Biomarkers during early healing of extraction procedures: a prospective case series.Clinical oral investigations · 2025Article
- miR-671-5p as a diagnostic biomarker and therapeutic target in periodontitis via THBS1 regulation.Hereditas · 2025Article
- Article
- Effectiveness of a Salivary Testing System to Screen for Periodontal Disease: A Cross-Sectional Study from the NOSE Study.Journal of clinical medicine · 2025Article
- The potential of serum and salivary interleukin-1β and matrix metalloproteinase-8 as determinants of periodontitis grading.BMC oral health · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
To explore severity and progression biomarkers, we examined the clinical relevance of multiple cytokines and mediators involved in the inflammatory response in periodontitis. A cohort of 68 patients was enrolled in the study and periodontal status assessed by the current classification of periodontal diseases. Immune mediators present in saliva, of both patients and healthy controls, were quantified using a Legendplex-13 panel. Clinic parameters were significantly higher in PD patients compared with HC, with a strong significant association with the disease severity (stage) (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.