Evidence map›Paper›PMID 39125945›Full record

ArticleInternational journal of molecular sciences2024

Tick-Derived Peptide Blocks Potassium Channel TREK-1.

Canwei Du, Linyan Chen, Guohao Liu, Fuchu Yuan, Zheyang Zhang, Mingqiang Rong, Guoxiang Mo, Changjun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Canwei DuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.ORCID 0000-0003-4722-9403
Linyan ChenCollege of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Guohao LiuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Fuchu YuanNational & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, China.
Zheyang ZhangSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Mingqiang RongNational & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, China.
Guoxiang MoCollege of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Changjun LiuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.ORCID 0000-0001-5627-2812

Funding

Drug Development of Novel Antimicrobe 2021320122000783Frontiers Medical Center, Tianfu Jincheng Laboratory TFJC2023010007National Natural Science Foundation of China 82304448Natural Science Foundation of Hunan Province 2024JJ6225Scientific Research Fund of Hunan Provincial Education Department 22B0482
6 · The paper itself

Abstract

Ticks transmit a variety of pathogens, including rickettsia and viruses, when they feed on blood, afflicting humans and other animals. Bioactive components acting on inflammation, coagulation, and the immune system were reported to facilitate ticks' ability to suck blood and transmit tick-borne diseases. In this study, a novel peptide, IstTx, from an

Indexed as

PeptidesPotassium Channels, Tandem Pore DomainAmino Acid SequenceAnimalsHEK293 CellsHumansIxodesMolecular Docking SimulationPotassium Channel BlockersTicksPeptidesPotassium Channel Blockerspotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainacidificationinhibitionIstTxticksTREK-1 channel

Identifiers

PMID39125945
PMCPMC11312834

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.