Evidence map›Paper›PMID 39125932›Full record

ArticleInternational journal of molecular sciences2024

Functional Insights into the Sphingolipids C1P, S1P, and SPC in Human Fibroblast-like Synoviocytes by Proteomic Analysis.

Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas TimmProtein Analytics Group, Institute of Biochemistry, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0001-8569-7537
Christiane HildLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Gerhard LiebischInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0003-4886-0811
Markus RickertLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.
Guenter LochnitProtein Analytics Group, Institute of Biochemistry, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0003-0377-395X
Juergen SteinmeyerLaboratory for Experimental Orthopaedics, Department of Orthopaedics, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-4053-503X

Funding

Deutsche Forschungsgemeinschaft 426546972Dr. Reinhold Bisinger Foundation 39/2017
6 · The paper itself

Abstract

The (patho)physiological function of the sphingolipids ceramide-1-phosphate (C1P), sphingosine-1-phosphate (S1P), and sphingosylphosphorylcholine (SPC) in articular joints during osteoarthritis (OA) is largely unknown. Therefore, we investigated the influence of these lipids on protein expression by fibroblast-like synoviocytes (FLSs) from OA knees. Cultured human FLSs (

Indexed as

CeramidesFibroblastsLysophospholipidsProteomicsSphingosineSynoviocytesAgedCells, CulturedFemaleHumansInterleukin-1betaMaleMiddle AgedOsteoarthritisOsteoarthritis, KneePhosphorylcholineceramide 1-phosphateCeramidesInterleukin-1betaLysophospholipidsPhosphorylcholineSphingolipidsSphingosinesphingosine 1-phosphatesphingosine phosphorylcholineceramide-1-phosphatefunctionsinflammationlysosphingomyelinmass spectrometryosteoarthritisproteomicssphingolipidsphingosine-1-phosphatesphingosylphosphorylcholine

Identifiers

PMID39125932
PMCPMC11313292

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.