One-Stage Pathway from Hollongdione to C17-Alkyne and Vinyl Chloride Following Mannich Bases and Carboxylic Acid.

Zarema Galimova, Irina Smirnova, Alexander Lobov, Dmitriy Polovyanenko, Tatyana Rybalova, Oxana Kazakova

Abstract read

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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Zarema GalimovaUfa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71, pr. Oktyabrya, 450054 Ufa, Russia.

Irina SmirnovaUfa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71, pr. Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0001-7176-505X

Alexander LobovUfa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71, pr. Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0002-9223-508X

Dmitriy PolovyanenkoN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.

Tatyana RybalovaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, 630090 Novosibirsk, Russia.ORCID 0000-0003-2398-5271

Oxana KazakovaUfa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71, pr. Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0002-5606-1588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hollongdione is the first recorded example of the occurrence of a dammarane hexanor-triterpene in nature possessing antiviral and cytotoxic activity. Its simple one-stage transformation into compounds with terminal alkyne and vinyl chloride fragments via the interaction with phosphorus halides is reported. The copper(I)-catalyzed Mannich reaction of 3-oxo-22,23,24,25,26,27-hexanor-dammar-20(21)-in

Indexed as

AlkynesCarboxylic AcidsMannich BasesVinyl ChlorideCatalysisMagnetic Resonance SpectroscopyMolecular StructureTriterpenesAlkynesCarboxylic AcidsMannich BasesTriterpenesVinyl Chloridealkynedammarane triterpenoidshollongdionehollongdionoic acidMannich basevinyl chloride

Identifiers

PMID39125926

DOI10.3390/ijms25158356

PMCPMC11313329

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.