Evidence map›Paper›PMID 39125917›Full record

ArticleInternational journal of molecular sciences2024

Assessment of Tie2-Rejuvenated Nucleus Pulposus Cell Transplants from Young and Old Patient Sources Demonstrates That Age Still Matters.

Yuto Otani, Jordy Schol, Daisuke Sakai, Yoshihiko Nakamura, Kosuke Sako, Takayuki Warita, Shota Tamagawa, Luca Ambrosio, Daiki Munesada, Shota Ogasawara and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuto OtaniDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Jordy ScholDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Daisuke SakaiDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-4189-9270
Yoshihiko NakamuraDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Kosuke SakoDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Takayuki WaritaDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Shota TamagawaDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0002-5384-8158
Luca AmbrosioDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-2424-1274
Daiki MunesadaDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0009-0008-9659-1904
Shota OgasawaraDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Erika MatsushitaDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Asami KawachiDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Mitsuru NaikiTUNZ Pharma Corporation, Osaka 541-0046, Japan.
Masato SatoDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-4049-7325
Masahiko WatanabeDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0001-9038-0446

Funding

TUNZ Pharma Corporation
6 · The paper itself

Abstract

Cell transplantation is being actively explored as a regenerative therapy for discogenic back pain. This study explored the regenerative potential of Tie2

Indexed as

Nucleus PulposusReceptor, TIE-2AdolescentAdultAgedAge FactorsAnimalsCell DifferentiationCell ProliferationCells, CulturedFemaleHumansIntervertebral DiscIntervertebral Disc DegenerationMaleMiddle AgedReceptor, TIE-2TEK protein, humancell therapydisc degenerationintervertebral disclow back painpreclinical modelprogenitor cellsregenerationTie2

Identifiers

PMID39125917
PMCPMC11312270

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.