Evidence map›Paper›PMID 39125915›Full record

ArticleInternational journal of molecular sciences2024

Role of Csdc2 in Regulating Secondary Hair Follicle Growth in Cashmere Goats.

Heqing Zhu, Yingying Li, He Xu, Yuehui Ma, Göran Andersson, Erik Bongcam-Rudloff, Tiantian Li, Jie Zhang, Yan Li, Jilong Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heqing ZhuCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Yingying LiCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
He XuCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Yuehui MaState Key Laboratory of Animal Biotech Breeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID 0000-0001-9526-1454
Göran AnderssonDepartment of Animal Biosciences, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.ORCID 0000-0001-5131-3144
Erik Bongcam-RudloffDepartment of Animal Biosciences, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.ORCID 0000-0002-1947-8288
Tiantian LiCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Jie ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Yan LiCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.
Jilong HanCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.ORCID 0000-0001-9747-8163
Min YangCollege of Animal Science and Technology, Shihezi University, Shihezi 832061, China.ORCID 0009-0002-2065-6253

Funding

International Science and Technology Cooperation Project of Shihezi University No. GJHZ202307Livestock Breeding Research Foundation of Shihezi University No. YZZX202005National Natural Science Foundation of China No. 31802045National Natural Science Foundation of China No. 32060745
6 · The paper itself

Abstract

Cashmere goats possess two types of hair follicles, with the secondary hair follicles producing valuable cashmere fiber used for textiles. The growth of cashmere exhibits a seasonal pattern arising from photoperiod change. Transcription factors play crucial roles during this process. The transcription factor, cold-shock domain, containing C2 (Csdc2) plays a crucial role in modulating cell proliferation and differentiation. Our preceding research indicated that the expression of Csdc2 changes periodically during anagen to telogen. However, the mechanisms of Csdc2 in regulating SHF growth remain unclear. Here, we found that the knockdown of Csdc2 inhibits the proliferation of dermal papilla cells. ChIP-Seq analysis showed that Csdc2 had a unique DNA binding motif in SHFs. Through conjoint analysis of ChIP-Seq and RNA-Seq, we revealed a total of 25 candidate target genes of Csdc2. Notably, we discovered a putative Csdc2 binding site within roundabout guidance receptor 2 (

Indexed as

GoatsHair FollicleAnimalsBinding SitesCell ProliferationGene Expression RegulationTranscription FactorsTranscription FactorsCashmere goatChIP-SeqCsdc2hair follicleRobo2

Identifiers

PMID39125915
PMCPMC11313070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.