Evidence map›Paper›PMID 39125907›Full record

ArticleInternational journal of molecular sciences2024

Proteomic Analysis Reveals Physiological Activities of Aβ Peptide for Alzheimer's Disease.

Xiaorui Ai, Zeyu Cao, Zhaoru Ma, Qinghuan Liu, Wei Huang, Taolei Sun, Jing Li, Chenxi Yang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaorui AiSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Zeyu CaoSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Zhaoru MaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Qinghuan LiuSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Wei HuangSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Taolei SunSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Jing LiSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.ORCID 0009-0003-5506-7093
Chenxi YangSchool of Biological Science & Medical Engineering, Southeast University, No. 2 Sipailou, Nanjing 210096, China.ORCID 0000-0003-3219-704X

Funding

National Natural Science Foundation of China 21703163National Natural Science Foundation of China 52372271the Fundamental Research Funds for the Central Universities 104972024KFYjc0077
6 · The paper itself

Abstract

With the rapid progress in deciphering the pathogenesis of Alzheimer's disease (AD), it has been widely accepted that the accumulation of misfolded amyloid β (Aβ) in the brain could cause the neurodegeneration in AD. Although much evidence demonstrates the neurotoxicity of Aβ, the role of Aβ in the nervous system are complex. However, more comprehensive studies are needed to understand the physiological effect of Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesProteomicsAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCell Line, TumorCytoskeletal ProteinsEzrinHumansMAP Kinase Signaling SystemMicrotubule-Associated ProteinsPeptide FragmentsPhosphatidylinositol 3-KinasesProteomeProto-Oncogene Proteins c-aktAmyloid beta-Peptidesamyloid beta-protein (1-40)Amyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanCytoskeletal ProteinsEzrinMicrotubule-Associated ProteinsPeptide FragmentsPhosphatidylinositol 3-KinasesProteomeProto-Oncogene Proteins c-akttau ProteinsAlzheimer’s diseaseamyloid βmass spectrometryneurodegenerationproteomics

Identifiers

PMID39125907
PMCPMC11313142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.