Evidence map›Paper›PMID 39125884›Full record

ReviewInternational journal of molecular sciences2024

Advancements of CRISPR-Mediated Base Editing in Crops and Potential Applications in

Xuefei Yang, Ping Zhu, Jinshan Gui

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xuefei YangState Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
Ping ZhuState Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
Jinshan GuiState Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.

Funding

National Natural Science Foundation of China 32022055Science and Technology Innovation 2030--Major Project 2023ZD04057
6 · The paper itself

Abstract

Base editing represents a cutting-edge genome editing technique that utilizes the CRISPR system to guide base deaminases with high precision to specific genomic sites, facilitating the targeted alteration of individual nucleotides. Unlike traditional gene editing approaches, base editing does not require DNA double-strand breaks or donor templates. It functions independently of the cellular DNA repair machinery, offering significant advantages in terms of both efficiency and accuracy. In this review, we summarize the core design principles of various DNA base editors, their distinctive editing characteristics, and tactics to refine their efficacy. We also summarize their applications in crop genetic improvement and explore their potential contributions to forest genetic engineering.

Indexed as

CRISPR-Cas SystemsCrops, AgriculturalGene EditingPopulusBase SequencePlant Breedingbase editorCRISPR-Cas9cropgenome editingPopulus

Identifiers

PMID39125884
PMCPMC11313136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.