Evidence map›Paper›PMID 39125761›Full record

ReviewInternational journal of molecular sciences2024

MiR-223-3p in Cancer Development and Cancer Drug Resistance: Same Coin, Different Faces.

Davide Barbagallo, Donatella Ponti, Barbara Bassani, Antonino Bruno, Laura Pulze, Shreya A Akkihal, Jonahunnatha N George-William, Rohit Gundamaraju, Paola Campomenosi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  15. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Davide BarbagalloDepartment of Biomedical and Biotechnological Sciences, Section of Biology and Genetics "Giovanni Sichel", University of Catania, Via Santa Sofia 89, 95123 Catania, Italy.ORCID 0000-0001-5331-4554
Donatella PontiDepartment of Medical-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Corso della Repubblica 79, 04100 Latina, Italy.
Barbara BassaniLaboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Via Fantoli 16/15, 20138 Milano, Italy.ORCID 0000-0002-8002-1607
Antonino BrunoLaboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Via Fantoli 16/15, 20138 Milano, Italy.ORCID 0000-0002-4790-0861
Laura PulzeDepartment of Biotechnology and Life Sciences, DBSV, University of Insubria, Via J.H. Dunant 3, 21100 Varese, Italy.
Shreya A AkkihalIndependent Researcher, 35004 SE Swenson St, Snoqualmie, WA 98065, USA.ORCID 0009-0004-5932-8227
Jonahunnatha N George-WilliamDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi, 93, 20054 Segrate, Italy.ORCID 0000-0001-7682-1241
Rohit GundamarajuDepartment of Laboratory Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.ORCID 0000-0001-5875-3003
Paola CampomenosiDepartment of Biotechnology and Life Sciences, DBSV, University of Insubria, Via J.H. Dunant 3, 21100 Varese, Italy.ORCID 0000-0002-8853-1134

Funding

Italian Ministry of University and Research 20225AZ22F
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are mighty post-transcriptional regulators in cell physiology and pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in various cancer types. MiR-223 has established roles in hematopoiesis, inflammation, and most cancers, where it can act as either an oncogenic or oncosuppressive miRNA, depending on specific molecular landscapes. MiR-223 has also been linked to either the sensitivity or resistance of cancer cells to treatments in a context-dependent way. Through this detailed review, we highlight that for some cancers (i.e., breast, non-small cell lung carcinoma, and glioblastoma), the oncosuppressive role of miR-223 is consistently reported in the literature, while for others (i.e., colorectal, ovarian, and pancreatic cancers, and acute lymphocytic leukemia), an oncogenic role prevails. In prostate cancer and other hematological malignancies, although an oncosuppressive role is frequently described, there is less of a consensus. Intriguingly,

Indexed as

Drug Resistance, NeoplasmGene Expression Regulation, NeoplasticMicroRNAsNeoplasmsAnimalsHumansMicroRNAsMIR223, humanbiomarkercancercancer immunitychemoresistancediagnosisinflammationmicroRNAmiR-223-3pprognosisradioresistance

Identifiers

PMID39125761
PMCPMC11311375

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.