Evidence map›Paper›PMID 39125745›Full record

ArticleInternational journal of molecular sciences2024

Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study.

Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Keiichi Hirono, Naoki Nishida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shojiro IchimataDepartment of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-7305-8137
Yukiko HataDepartment of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Koji YoshidaDepartment of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Keiichi HironoDepartment of Pediatrics, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-4224-9053
Naoki NishidaDepartment of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-6921-1768

Funding

JSPS KAKENHI grant JP20K18979
6 · The paper itself

Abstract

Left-to-right differences in the histopathologic patterns of transthyretin-derived amyloid (ATTR) deposition in the atria of older adults have not yet been investigated. Hence, this study evaluated heart specimens from 325 serial autopsy subjects. The amount of ATTR deposits in the seven cardiac regions, including both sides of atria and atrial appendages, was evaluated semiquantitatively. Using digital pathology, we quantitatively evaluated the immunohistochemical deposition burden of ATTR in the myocardium. We identified 20 sporadic ATTR cardiac amyloidosis cases (nine males). All patients had ATTR deposition in the left atrial regions of the myocardium. In the semiquantitative analysis, 14 of the 20 cases showed more severe ATTR deposition on the left atrial regions than on the right side, with statistically significant differences in the pathology grading (

Indexed as

AutopsyHeart AtriaPrealbuminAgedAged, 80 and overAmyloidAmyloid Neuropathies, FamilialAmyloidosisFemaleHumansMaleMiddle AgedMyocardiumAmyloidPrealbuminatrial natriuretic factoratriumcardiac amyloidosisgiant celltransthyretin

Identifiers

PMID39125745
PMCPMC11311325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.