Overexpression of miR-199b-5p in Colony Forming Unit-Hill's Colonies Positively Mediates the Inflammatory Response in Subclinical Cardiovascular Disease Model: Metformin Therapy Attenuates Its Expression.

Sherin Bakhashab, Rosie Barber, Josie O'Neill, Catherine Arden, Jolanta U Weaver

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

MiR-199b-5p inhibition improves inflammation and oxidative stress damage in OA-induced non-alcoholic fatty liver disease through targeting SIRT1.BMC gastroenterology · 2025
Article

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5 · Who and what money

Authors and funding

5 authors.

Sherin BakhashabBiochemistry Department, King Abdulaziz University, P.O. Box 80218, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-1580-0409

Rosie BarberTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Josie O'NeillTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Catherine ArdenBiosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-3642-3182

Jolanta U WeaverTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Funding

Diabetes Research and Wellness Foundation NoneDiabetes Research Fund at Queen Elizabeth Hospital, UK None

6 · The paper itself

Abstract

Well-controlled type 1 diabetes (T1DM) is characterized by inflammation and endothelial dysfunction, thus constituting a suitable model of subclinical cardiovascular disease (CVD). miR-199b-5p overexpression in murine CVD has shown proatherosclerotic effects. We hypothesized that miR-199b-5p would be overexpressed in subclinical CVD yet downregulated following metformin therapy. Inflammatory and vascular markers were measured in 29 individuals with T1DM and 20 matched healthy controls (HCs). miR-199b-5p expression in CFU-Hill's colonies was analyzed from each study group, and correlations with inflammatory/vascular health indices were evaluated. Significant upregulation of miR-199b-5p was observed in T1DM, which was significantly downregulated by metformin. miR-199b-5p correlated positively with vascular endothelial growth factor-D and c-reactive protein (CRP: nonsignificant). ROC analysis determined miR-199b-5p to define subclinical CVD by discriminating between HCs and T1DM individuals. ROC analyses of HbA1c and CRP showed that the upregulation of miR-199b-5p in T1DM individuals defined subclinical CVD at HbA1c > 44.25 mmol and CRP > 4.35 × 10

Indexed as

Cardiovascular DiseasesMetforminMicroRNAsAdultBiomarkersCase-Control StudiesC-Reactive ProteinDiabetes Mellitus, Type 1FemaleGene Expression RegulationHumansHypoglycemic AgentsInflammationJagged-1 ProteinMaleMiddle AgedBiomarkersC-Reactive ProteinHypoglycemic AgentsJAG1 protein, humanJagged-1 ProteinMetforminMicroRNAsmirn199 microRNA, humanSirtuin 1STAT3 Transcription FactorCFU-Hill coloniesmetforminmiR-199b-5psubclinical CVD

Identifiers

PMID39125657

DOI10.3390/ijms25158087

PMCPMC11311364

What OpenQuestion holds

Texttitle and abstract

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.