Evidence map›Paper›PMID 39125637›Full record

ArticleInternational journal of molecular sciences2024

Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation.

Aditya K Singh, Jully Singh, Nana A Goode, Fernanda Laezza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In Vivo Expression of an SCA27A-LinkedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aditya K SinghDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Jully SinghDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Nana A GoodeDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Fernanda LaezzaDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-1141-1852

Funding

Probing brain circuit and behavior with protein:protein interaction modulatorsR01MH132226 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Fernanda Laezza, Jia Zhou · 2023 to 2026
$3.2M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Neurotoxicology of deltamethrin in the developing brainR01ES031823 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GREEN, THOMAS ARTHUR, LAEZZA, FERNANDA · 2020 to 2024
$2.8M
NIEHS NIH HHS R01 ES031823NIMH NIH HHS R01 MH124351NIMH NIH HHS R01 MH132226
6 · The paper itself

Abstract

The signaling complex around voltage-gated sodium (Nav) channels includes accessory proteins and kinases crucial for regulating neuronal firing. Previous studies showed that one such kinase, WEE1-critical to the cell cycle-selectively modulates Nav1.2 channel activity through the accessory protein fibroblast growth factor 14 (FGF14). Here, we tested whether WEE1 exhibits crosstalk with the AKT/GSK3 kinase pathway for coordinated regulation of FGF14/Nav1.2 channel complex assembly and function. Using the in-cell split luciferase complementation assay (LCA), we found that the WEE1 inhibitor II and GSK3 inhibitor XIII reduce the FGF14/Nav1.2 complex formation, while the AKT inhibitor triciribine increases it. However, combining WEE1 inhibitor II with either one of the other two inhibitors abolished its effect on the FGF14/Nav1.2 complex formation. Whole-cell voltage-clamp recordings of sodium currents (I

Indexed as

Cell Cycle ProteinsGlycogen Synthase Kinase 3NAV1.2 Voltage-Gated Sodium ChannelProtein-Tyrosine KinasesProto-Oncogene Proteins c-aktFibroblast Growth FactorsHEK293 CellsHumansSignal TransductionCell Cycle Proteinsfibroblast growth factor 14Fibroblast Growth FactorsGlycogen Synthase Kinase 3NAV1.2 Voltage-Gated Sodium ChannelProtein-Tyrosine KinasesProto-Oncogene Proteins c-aktWEE1 protein, humanfibroblast growth factorskinase inhibitorssplit luciferase assayvoltage-gated sodium channels

Identifiers

PMID39125637
PMCPMC11311446

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.