Evidence map›Paper›PMID 39125618›Full record

ArticleInternational journal of molecular sciences2024

Flow and On-Water Synthesis and Cancer Cell Cytotoxicity of Caffeic Acid Phenethyl Amide (CAPA) Derivatives.

Anthony Saucedo, Muppidi Subbarao, Mauricio Jemal, Nakya L Mesa-Diaz, Jadyn L Smith, Alexandra Vernaza, Liqin Du, Sean M Kerwin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anthony SaucedoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Muppidi SubbaraoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Mauricio JemalMaterials Science, Engineering, and Commercialization Program, Texas State University, San Marcos, TX 78666, USA.
Nakya L Mesa-DiazDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Jadyn L SmithDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.ORCID 0009-0000-0788-5129
Alexandra VernazaDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.ORCID 0000-0001-5829-0459
Liqin DuDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
Sean M KerwinDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.ORCID 0000-0001-8432-6558

Funding

South Texas Doctoral Bridge ProgramR25GM102783 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OYAJOBI, BABATUNDE OLUKAYODE, WHITTEN, STEVEN T · 2013 to 2022
$3.1M
Discovery of New Differentiation Agents for Neuroblastoma TherapyR15CA213199 · NCI · TEXAS STATE UNIVERSITY · PI DU, LIQIN · 2017 to 2017
$462k
National Science Foundation 1955432NCI NIH HHS R15 CA213199NIGMS NIH HHS R25 GM102783NIH HHS 1R15CA213199-01A1NIH HHS 1R25GM102783-10A1
6 · The paper itself

Abstract

Caffeic acid phenethyl ester (CAPE) is a phenolic natural product with a wide range of biological activities, including anticancer activity; however, the ester group of CAPE is metabolically labile. The corresponding amide, CAPA, has improved metabolic stability but limited anticancer activity relative to CAPE. We report the synthesis using flow and on-water Wittig reaction approaches of five previously reported and five novel CAPA analogues. All of these analogues lack the reactive catechol functionality of CAPA and CAPE. Cytotoxicity studies of CAPE, CAPA, and these CAPA analogues in HeLa and BE(2)-C cells were carried out. Surprisingly, we found that CAPA is cytotoxic against the neuroblastoma BE(2)-C cell line (IC

Indexed as

Antineoplastic AgentsCaffeic AcidsPhenylethyl AlcoholAmidesCell Line, TumorCell SurvivalHeLa CellsHumansWaterAmidesAntineoplastic Agentscaffeic acid phenethyl esterCaffeic AcidsPhenylethyl AlcoholWateranticancerflow synthesisnatural productneuroblastomaon-water synthesisWittig reaction

Identifiers

PMID39125618
PMCPMC11312412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.